Effects of Transglutaminase 2 Inhibition on Ventilator-Induced Lung Injury
DC Field | Value | Language |
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dc.contributor.author | Suh, In Bum | - |
dc.contributor.author | Yoon, Dae Wui | - |
dc.contributor.author | Oh, Won-Oak | - |
dc.contributor.author | Lee, Eun Joo | - |
dc.contributor.author | Min, Kyung Hoon | - |
dc.contributor.author | Hur, Gyu Young | - |
dc.contributor.author | Lee, Seung Heon | - |
dc.contributor.author | Lee, Sung Yong | - |
dc.contributor.author | Lee, Sang Yeub | - |
dc.contributor.author | Shin, Chol | - |
dc.contributor.author | Shim, Jae Jeong | - |
dc.contributor.author | In, Kwang Ho | - |
dc.contributor.author | Kang, Kyung Ho | - |
dc.contributor.author | Kim, Je Hyeong | - |
dc.date.accessioned | 2021-09-05T09:53:40Z | - |
dc.date.available | 2021-09-05T09:53:40Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-04 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98809 | - |
dc.description.abstract | This study was performed to examine the role of transglutaminase 2 (TG2) in ventilator-induced lung injury (VILI). C57BL/6 mice were divided into six experimental groups: 1) control group; 2) lipopolysaccharide (LPS) group; 3) lung protective ventilation (LPV) group; 4) VILI group; 5) VILI with cystamine, a TG2 inhibitor, pretreatment (Cyst+VILI) group; and 6) LPV with cystamine pretreatment (Cyst+LPV) group. Acute lung injury (ALI) score, TG2 activity and gene expression, inflammatory cytokines, and nuclear factor-kappa B (NF-kappa B) activity were measured. TG2 activity and gene expression were significantly increased in the VILI group (P<0.05). Cystamine pretreatment significantly decreased TG2 activity and gene expression in the Cyst+VILI group (P<0.05). Inflammatory cytokines were higher in the VILI group than in the LPS and LPV groups (P<0.05), and significantly lower in the Cyst+VILI group than the VILI group (P<0.05). NF-kappa B activity was increased in the VILI group compared with the LPS and LPV groups (P<0.05), and significantly decreased in the Cyst+VILI group compared to the VILI group (P=0.029). The ALI score of the Cyst+VILI group was lower than the VILI group, but the difference was not statistically significant (P=0.105). These results suggest potential roles of TG2 in the pathogenesis of VILI. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.subject | RESPIRATORY-DISTRESS-SYNDROME | - |
dc.subject | TISSUE TRANSGLUTAMINASE | - |
dc.subject | MOUSE MODEL | - |
dc.subject | CELL-DEATH | - |
dc.subject | IN-VIVO | - |
dc.subject | INFLAMMATION | - |
dc.subject | DISEASE | - |
dc.subject | INTERLEUKIN-6 | - |
dc.subject | EXPRESSION | - |
dc.subject | SURVIVAL | - |
dc.title | Effects of Transglutaminase 2 Inhibition on Ventilator-Induced Lung Injury | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Won-Oak | - |
dc.contributor.affiliatedAuthor | Lee, Eun Joo | - |
dc.contributor.affiliatedAuthor | Min, Kyung Hoon | - |
dc.contributor.affiliatedAuthor | Hur, Gyu Young | - |
dc.contributor.affiliatedAuthor | Lee, Seung Heon | - |
dc.contributor.affiliatedAuthor | Lee, Sung Yong | - |
dc.contributor.affiliatedAuthor | Lee, Sang Yeub | - |
dc.contributor.affiliatedAuthor | Shin, Chol | - |
dc.contributor.affiliatedAuthor | Shim, Jae Jeong | - |
dc.contributor.affiliatedAuthor | In, Kwang Ho | - |
dc.contributor.affiliatedAuthor | Kang, Kyung Ho | - |
dc.contributor.affiliatedAuthor | Kim, Je Hyeong | - |
dc.identifier.doi | 10.3346/jkms.2014.29.4.556 | - |
dc.identifier.scopusid | 2-s2.0-84899881934 | - |
dc.identifier.wosid | 000335377900014 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.29, no.4, pp.556 - 563 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 29 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 556 | - |
dc.citation.endPage | 563 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001868133 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | RESPIRATORY-DISTRESS-SYNDROME | - |
dc.subject.keywordPlus | TISSUE TRANSGLUTAMINASE | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | INTERLEUKIN-6 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | Acute Lung Injury | - |
dc.subject.keywordAuthor | Respiratory Distress Syndrome, Adult | - |
dc.subject.keywordAuthor | Respiration, Artificial | - |
dc.subject.keywordAuthor | Ventilator-Induced Lung Injury | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Transglutaminase 2 | - |
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