Effective Antifouling Using Quorum-Quenching Acylase Stabilized in Magnetically-Separable Mesoporous Silica
- Authors
- Lee, Byoungsoo; Yeon, Kyung-Min; Shim, Jongmin; Kim, Sang-Ryoung; Lee, Chung-Hak; Lee, Jinwoo; Kim, Jungbae
- Issue Date
- 4월-2014
- Publisher
- AMER CHEMICAL SOC
- Citation
- BIOMACROMOLECULES, v.15, no.4, pp.1153 - 1159
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMACROMOLECULES
- Volume
- 15
- Number
- 4
- Start Page
- 1153
- End Page
- 1159
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/98813
- DOI
- 10.1021/bm401595q
- ISSN
- 1525-7797
- Abstract
- Highly effective antifouling was achieved by immobilizing and stabilizing an acylase, disrupting bacterial cell-to-cell communication, in the form of cross-linked enzymes in magnetically separable mesoporous silica. This so-called "quorum-quenching" acylase (AC) was adsorbed into spherical mesoporous silica (S-MPS) with magnetic nanoparticles (Mag-S-MPS), and further cross-linked for the preparation of nanoscale enzyme reactors of AC in Mag-S-MPS (NER-AC/Mag-S-MPS). NER-AC effectively stabilized the AC activity under rigorous shaking at 200 rpm for 1 month, while free and adsorbed AC lost more than 90% of their initial activities in the same condition within 1 and 10 days, respectively. When applied to the membrane filtration for advanced water treatment, NER-AC efficiently alleviated the membrane surface, thereby enhancing the filtration performance separable NER-AC, as an effective and sustainable antifouling m for water reclamation. biofilm maturation of Pseudomonas aeruginosa PAO1 on the membrane surface, thereby enhancing the filtration performance by preventing membrane fouling. Highly stable and magnetically separable NER-AC, as an effective and sustainable antifouling material, has a great potential to be used in the membrane filtration for water reclamation.
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