Plasminogen activator inhibitor-1 4G/5G and the MTHFR 677C/T polymorphisms and susceptibility to polycystic ovary syndrome: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-05T10:04:29Z | - |
dc.date.available | 2021-09-05T10:04:29Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-04 | - |
dc.identifier.issn | 0301-2115 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98849 | - |
dc.description.abstract | The aim of this study was to explore whether the plasminogen activator inhibitor-1 (PAI-1) 4G/5G and the methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphisms are associated with susceptibility to polycystic ovary syndrome (PCOS). Meta-analyses were conducted to determine the association between the PAI-1 4G/5G and MTHFR 677C/T polymorphisms and PCOS using: (1) allele contrast (2) homozygote contrast, (3) recessive, and (4) dominant models. For meta-analysis, nine studies of the PAI-1 4G/5G polymorphism with 2384 subjects (PCOS, 1615; controls, 769) and eight studies of the MTHFR 677C/T polymorphism with 1270 study subjects were included. Meta-analysis of all study subjects showed no association between PCOS and the PAI-1 4G allele (OR = 0.949, 95% CI = 0.671-1.343, p = 0.767). Stratification by ethnicity, however, indicated a significant association between the PAI-1 4G allele and PCOS in Turkish and Asian populations (OR = 0.776, 95% CI = 0.602-0.999, p = 0.049; OR = 1.749, 95% CI = 1.297-2.359, p = 2.5 x 10(-5) respectively). In addition, metaanalysis indicated an association between PCOS and the PAI-1 4G4G + 4G5G genotype in Europeans (OR= 1.406, 95% CI = 1.025-1.928, p = 0.035). However, meta-analysis of all study subjects showed no association between PCOS and the MTHFR 677T allele (OR = 0.998, 95% CI = 0.762-1.307, p = 0.989), including Europeans (OR = 0.806,95% CI = 0.610-1.063, p = 0.126). Meta-analysis showed no association between PCOS and the MTHFR 677C/T polymorphism using homozygote contrast, and recessive and dominant models. In conclusion, meta-analysis suggests the PAI-1 4G/5G polymorphism is associated with susceptibility to PCOS in European, Turkish, and Asian populations, but the MTHFR 677C/T polymorphism is not associated with susceptibility to PCOS in Europeans. (C) 2013 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | GENOME SCAN METAANALYSIS | - |
dc.subject | C677T POLYMORPHISM | - |
dc.subject | PAI-1 GENE | - |
dc.subject | WOMEN | - |
dc.subject | REDUCTASE | - |
dc.subject | HOMOCYSTEINE | - |
dc.subject | MISCARRIAGE | - |
dc.subject | PROMOTER | - |
dc.subject | INSULIN | - |
dc.title | Plasminogen activator inhibitor-1 4G/5G and the MTHFR 677C/T polymorphisms and susceptibility to polycystic ovary syndrome: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1016/j.ejogrb.2013.12.030 | - |
dc.identifier.scopusid | 2-s2.0-84898059054 | - |
dc.identifier.wosid | 000335432000002 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, v.175, pp.8 - 14 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | - |
dc.citation.title | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | - |
dc.citation.volume | 175 | - |
dc.citation.startPage | 8 | - |
dc.citation.endPage | 14 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalResearchArea | Reproductive Biology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Reproductive Biology | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | GENOME SCAN METAANALYSIS | - |
dc.subject.keywordPlus | C677T POLYMORPHISM | - |
dc.subject.keywordPlus | PAI-1 GENE | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | REDUCTASE | - |
dc.subject.keywordPlus | HOMOCYSTEINE | - |
dc.subject.keywordPlus | MISCARRIAGE | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordAuthor | PCOS | - |
dc.subject.keywordAuthor | PAL-1 | - |
dc.subject.keywordAuthor | MTHFR | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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