Immunomodulatory Effects of Balneotherapy with Hae-Un-Dae Thermal Water on Imiquimod-Induced Psoriasis-Like Murine Model
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Bok | - |
dc.contributor.author | Lee, Jun Young | - |
dc.contributor.author | Lee, Hye Jin | - |
dc.contributor.author | Yun, Seong Taek | - |
dc.contributor.author | Lee, Jong Tae | - |
dc.contributor.author | Kim, Hong Jig | - |
dc.contributor.author | Yu, Dong Soo | - |
dc.contributor.author | Woo, So Youn | - |
dc.contributor.author | Kim, Jin-Wou | - |
dc.date.accessioned | 2021-09-05T10:10:17Z | - |
dc.date.available | 2021-09-05T10:10:17Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-04 | - |
dc.identifier.issn | 1013-9087 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98891 | - |
dc.description.abstract | Background: Balneotherapy, although not a well-established dermatological treatment, is thought to have therapeutic properties for psoriasis and is used as an alternative treatment modality throughout the world. Objective: To evaluate the mechanism underlying the therapeutic immunologic effects of thermomineral water. Methods: A murine model of imiquimod-induced psoriasis-like skin inflammation was used for evaluating the therapeutic effects of balneotherapy with Hae-Un-Dae hot spring mineral water. The clinical improvements were evaluated by a dermatologist. Lesional cytokines, including interleukin (IL)-17A, IL-23, and IL-22, were quantitatively measured by real-time reverse transcriptase polymerase chain reaction. Serum levels of interferon-gamma, IL-4, IL-5, and IL-17A were measured by enzyme- linked immunosorbent assay. T cell proportions in the spleen were evaluated by flow cytometry, and histopathological evaluation of the skin was also performed. Results: The mineral water balneotherapy group showed faster improvement in skin erythema and scales than the distilled water bathing group. A substantial reduction was observed in the lesional mRNA levels of IL-17A and IL-23 in the mineral water group. Serum levels of IL-4 and IL-5 were significantly decreased in the mineral water group but hot in the distilled water group. Normalized T cell proportions were observed after bathing. Conclusion: Balneotherapy showed immunomodulatory effects in a psoriasis-like murine model. Balneotherapy suppressed lesional IL-23 and IL-17A, which are important cytokines in the pathogenesis of psoriasis. These results suggest that balneotherapy can be used as an effective and safe treatment for psoriasis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN DERMATOLOGICAL ASSOC | - |
dc.subject | AVENE SPRING WATER | - |
dc.subject | CHRONIC PLAQUE PSORIASIS | - |
dc.subject | MINERAL-WATER | - |
dc.subject | ANTIPSORIATIC ACTION | - |
dc.subject | HEALTHY-SUBJECTS | - |
dc.subject | SPAS | - |
dc.subject | EXPRESSION | - |
dc.subject | KERATINOCYTES | - |
dc.subject | TRENTINO | - |
dc.subject | INTERFERES | - |
dc.title | Immunomodulatory Effects of Balneotherapy with Hae-Un-Dae Thermal Water on Imiquimod-Induced Psoriasis-Like Murine Model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yun, Seong Taek | - |
dc.identifier.doi | 10.5021/ad.2014.26.2.221 | - |
dc.identifier.scopusid | 2-s2.0-84901784845 | - |
dc.identifier.wosid | 000336344300013 | - |
dc.identifier.bibliographicCitation | ANNALS OF DERMATOLOGY, v.26, no.2, pp.221 - 230 | - |
dc.relation.isPartOf | ANNALS OF DERMATOLOGY | - |
dc.citation.title | ANNALS OF DERMATOLOGY | - |
dc.citation.volume | 26 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 221 | - |
dc.citation.endPage | 230 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001872175 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | AVENE SPRING WATER | - |
dc.subject.keywordPlus | CHRONIC PLAQUE PSORIASIS | - |
dc.subject.keywordPlus | MINERAL-WATER | - |
dc.subject.keywordPlus | ANTIPSORIATIC ACTION | - |
dc.subject.keywordPlus | HEALTHY-SUBJECTS | - |
dc.subject.keywordPlus | SPAS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | KERATINOCYTES | - |
dc.subject.keywordPlus | TRENTINO | - |
dc.subject.keywordPlus | INTERFERES | - |
dc.subject.keywordAuthor | Bath | - |
dc.subject.keywordAuthor | Immunomodulation | - |
dc.subject.keywordAuthor | Mineral waters | - |
dc.subject.keywordAuthor | Psoriasis | - |
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