Pharmacokinetics and Metabolism of 4-O-Methylhonokiol in Rats
DC Field | Value | Language |
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dc.contributor.author | Yu, Hyung Eun | - |
dc.contributor.author | Oh, Soo Jin | - |
dc.contributor.author | Ryu, Je Kyung | - |
dc.contributor.author | Kang, Jong Soon | - |
dc.contributor.author | Hong, Jin Tae | - |
dc.contributor.author | Jung, Jae-Kyung | - |
dc.contributor.author | Han, Sang-Bae | - |
dc.contributor.author | Seo, Seung-Yong | - |
dc.contributor.author | Kim, Young Heui | - |
dc.contributor.author | Park, Song-Kyu | - |
dc.contributor.author | Kim, Hwan Mook | - |
dc.contributor.author | Lee, Kiho | - |
dc.date.accessioned | 2021-09-05T10:18:50Z | - |
dc.date.available | 2021-09-05T10:18:50Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-04 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98948 | - |
dc.description.abstract | The purpose of this study was to characterize the pharmacokinetics and metabolism of 4-O-methylhonokiol in rats. The absorption and disposition of 4-O-methylhonokiol were investigated in male Sprague-Dawley rats following a single intravenous (2 mg/kg) or oral (10 mg/kg) dose. Its metabolism was studied in vitro using rat liver microsomes and cytosol. 4-O-Methylhonokiol exhibited a high systemic plasma clearance and a large volume of distribution. The oral dose gave a peak plasma concentration of 24.1 +/- 3.3 ng/mL at 2.9 +/- 1.9 h and a low estimated bioavailability. 4-O-Methylhonokiol was rapidly metabolized and converted at least in part to honokiol in a concentration-dependent manner by cytochrome P450 in rat liver microsomes, predicting a high systemic clearance consistent with the pharmacokinetic results. It was also shown to be metabolized by glucuronidation and sulfation in rat liver microsomes and cytosol, respectively. 4-O-Methylhonokiol showed a moderate permeability with no apparent vectorial transport across Caco-2 cells, suggesting that intestinal permeation process is not likely to limit its oral absorption. Taken together, these results suggest that the rapid hepatic metabolism of 4-O-methylhonokiol could be the major reason for its high systemic clearance and low oral bioavailability. Copyright (c) 2013 John Wiley & Sons, Ltd. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | IN-VITRO METABOLISM | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | MEMORY IMPAIRMENT | - |
dc.subject | MAGNOLIA-OFFICINALIS | - |
dc.subject | ETHANOL EXTRACT | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | INTRAVENOUS BOLUS | - |
dc.subject | MOUSE MODEL | - |
dc.subject | HONOKIOL | - |
dc.subject | INHIBITION | - |
dc.title | Pharmacokinetics and Metabolism of 4-O-Methylhonokiol in Rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Song-Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Kiho | - |
dc.identifier.doi | 10.1002/ptr.5033 | - |
dc.identifier.scopusid | 2-s2.0-84898720686 | - |
dc.identifier.wosid | 000333704500012 | - |
dc.identifier.bibliographicCitation | PHYTOTHERAPY RESEARCH, v.28, no.4, pp.568 - 578 | - |
dc.relation.isPartOf | PHYTOTHERAPY RESEARCH | - |
dc.citation.title | PHYTOTHERAPY RESEARCH | - |
dc.citation.volume | 28 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 568 | - |
dc.citation.endPage | 578 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | IN-VITRO METABOLISM | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | MEMORY IMPAIRMENT | - |
dc.subject.keywordPlus | MAGNOLIA-OFFICINALIS | - |
dc.subject.keywordPlus | ETHANOL EXTRACT | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | INTRAVENOUS BOLUS | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | HONOKIOL | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordAuthor | pharmacokinetics | - |
dc.subject.keywordAuthor | 4-O-methylhonokiol | - |
dc.subject.keywordAuthor | metabolism | - |
dc.subject.keywordAuthor | honokiol | - |
dc.subject.keywordAuthor | neolignan | - |
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