Expression of beta-tubulin isotypes in urothelial carcinoma of the bladder
- Authors
- Choi, Jung-Woo; Kim, Younghye; Lee, Ju-Han; Kim, Young-Sik
- Issue Date
- 4월-2014
- Publisher
- SPRINGER
- Keywords
- Bladder cancer; Immunohistochemistry; Tubulin; Chemotherapy
- Citation
- WORLD JOURNAL OF UROLOGY, v.32, no.2, pp.347 - 352
- Indexed
- SCIE
SCOPUS
- Journal Title
- WORLD JOURNAL OF UROLOGY
- Volume
- 32
- Number
- 2
- Start Page
- 347
- End Page
- 352
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/98955
- DOI
- 10.1007/s00345-012-0993-z
- ISSN
- 0724-4983
- Abstract
- Our study aims to investigate the expressions of beta-tubulin isotypes and their significances in urothelial carcinoma of the bladder (UCB) as altered expression of a specific beta-tubulin isotype is associated with chemoresistance and poor prognosis in other malignancies. Expression of beta-tubulin isotypes was retrospectively examined in 342 UCB samples obtained from 1995 to 2010 by immunohistochemistry. TUBB1 (307/342, 89.8 %) was most frequently overexpressed in the cytoplasm of UCB cases, followed by TUBB4 (101/342, 29.5 %), TUBB2 (85/342, 24.9 %), and TUBB3 (60/342, 17.5 %). TUBB1 overexpression was associated with older age (p = 0.032), high WHO grade (p = 0.001), and advanced TNM stage (p = 0.006). High levels of TUBB2 expression were associated with high WHO grade (p < 0.001), advanced TNM stage (p < 0.001), and non-papillary growth pattern (p = 0.007). TUBB3 overexpression was related to high WHO grade (p = 0.029). In univariate and multivariate survival analyses, TUBB1 overexpression was associated with poor recurrence-free survival (RFS) rates of all cases (hazard ratio 1.98, p = 0.031) and of the patients with transurethral and/or partial resection (hazard ratio 2.12, p = 0.031). TUBB2 overexpression was correlated with a short RFS of the patients with T2-T4 stages (hazard ratio 3.48, p = 0.007). TUBB3 overexpression was related to a poor RFS of the patients undergoing radical cystectomy (hazard ratio 5.90, p = 0.002). High TUBB1, TUBB2, and TUBB3 expressions are associated with unfavorable clinicopathologic factors and are independent prognostic factors for recurrence-free survival of UCB.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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