Usefulness of N-terminal pro-B-type natriuretic peptide in patients admitted to the intensive care unit: a multicenter prospective observational study
DC Field | Value | Language |
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dc.contributor.author | Rhee, Chin Kook | - |
dc.contributor.author | Lim, So Yeon | - |
dc.contributor.author | Koh, Shin Ok | - |
dc.contributor.author | Choi, Won-Il | - |
dc.contributor.author | Lee, Young-Joo | - |
dc.contributor.author | Chon, Gyu Rak | - |
dc.contributor.author | Kim, Je Hyeong | - |
dc.contributor.author | Kim, Jae Yeol | - |
dc.contributor.author | Lim, Jaemin | - |
dc.contributor.author | Park, Sunghoon | - |
dc.contributor.author | Kim, Ho Cheol | - |
dc.contributor.author | Lee, Jin Hwa | - |
dc.contributor.author | Lee, Ji Hyun | - |
dc.contributor.author | Park, Jisook | - |
dc.contributor.author | Koh, Younsuck | - |
dc.contributor.author | Suh, Gee Young | - |
dc.contributor.author | Kim, Seok Chan | - |
dc.date.accessioned | 2021-09-05T10:38:16Z | - |
dc.date.available | 2021-09-05T10:38:16Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-03-10 | - |
dc.identifier.issn | 1471-2253 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99023 | - |
dc.description.abstract | Background: The role of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) as a prognostic factor in patients admitted to the intensive care unit (ICU) is not yet fully established. We aimed to determine whether NT-pro-BNP is predictive of ICU mortality in a multicenter cohort of critically ill patients. Methods: A total of 1440 patients admitted to 22 ICUs ( medical, 14; surgical, six; multidisciplinary, two) in 15 tertiary or university-affiliated hospitals between July 2010 and January 2011 were assessed. Patient data, including NT-pro-BNP levels and Simplified Acute Physiology Score ( SAPS) 3 scores, were recorded prospectively in a web-based database. Results: The median age was 64 years ( range, 53-73 years), and 906 ( 62.9%) patients were male. The median NT-pro-BNP level was 341 pg/mL ( 104-1,637 pg/mL), and the median SAPS 3 score was 57 ( range, 47-69). The ICU mortality rate was 18.9%, and hospital mortality was 24.5%. Hospital survivors showed significantly lower NT-pro-BNP values than nonsurvivors ( 245 pg/mL [ range, 82-1,053 pg/mL] vs. 875 pg/mL [ 241-5,000 pg/mL], respectively; p <0.001). In prediction of hospital mortality, the area under the curve (AUC) for NT-pro-BNP was 0.67 ( 95% confidence interval [CI], 0.64-0.70) and SAPS 3 score was 0.83 ( 95% CI, 0.81-0.85). AUC increment by adding NT-pro-BNP is minimal and likely no different to SAPS 3 alone. Conclusions: The NT-pro-BNP level was more elevated in nonsurvivors in a multicenter cohort of critically ill patients. However, there was little additional prognostic power when adding NT-pro-BNP to SAPS 3 score. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.subject | CRITICALLY-ILL PATIENTS | - |
dc.subject | ADMISSION SCORE | - |
dc.subject | VALIDATION | - |
dc.subject | CUSTOMIZATION | - |
dc.subject | POPULATION | - |
dc.subject | PREDICTOR | - |
dc.subject | MORTALITY | - |
dc.subject | FAILURE | - |
dc.subject | COHORT | - |
dc.subject | HEART | - |
dc.title | Usefulness of N-terminal pro-B-type natriuretic peptide in patients admitted to the intensive care unit: a multicenter prospective observational study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Je Hyeong | - |
dc.identifier.doi | 10.1186/1471-2253-14-16 | - |
dc.identifier.scopusid | 2-s2.0-84897941761 | - |
dc.identifier.wosid | 000334455400001 | - |
dc.identifier.bibliographicCitation | BMC ANESTHESIOLOGY, v.14 | - |
dc.relation.isPartOf | BMC ANESTHESIOLOGY | - |
dc.citation.title | BMC ANESTHESIOLOGY | - |
dc.citation.volume | 14 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.subject.keywordPlus | CRITICALLY-ILL PATIENTS | - |
dc.subject.keywordPlus | ADMISSION SCORE | - |
dc.subject.keywordPlus | VALIDATION | - |
dc.subject.keywordPlus | CUSTOMIZATION | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | PREDICTOR | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | FAILURE | - |
dc.subject.keywordPlus | COHORT | - |
dc.subject.keywordPlus | HEART | - |
dc.subject.keywordAuthor | N-terminal pro-B-type natriuretic peptide | - |
dc.subject.keywordAuthor | Intensive care unit | - |
dc.subject.keywordAuthor | Critical care | - |
dc.subject.keywordAuthor | Prognosis | - |
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