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Usefulness of N-terminal pro-B-type natriuretic peptide in patients admitted to the intensive care unit: a multicenter prospective observational study

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dc.contributor.authorRhee, Chin Kook-
dc.contributor.authorLim, So Yeon-
dc.contributor.authorKoh, Shin Ok-
dc.contributor.authorChoi, Won-Il-
dc.contributor.authorLee, Young-Joo-
dc.contributor.authorChon, Gyu Rak-
dc.contributor.authorKim, Je Hyeong-
dc.contributor.authorKim, Jae Yeol-
dc.contributor.authorLim, Jaemin-
dc.contributor.authorPark, Sunghoon-
dc.contributor.authorKim, Ho Cheol-
dc.contributor.authorLee, Jin Hwa-
dc.contributor.authorLee, Ji Hyun-
dc.contributor.authorPark, Jisook-
dc.contributor.authorKoh, Younsuck-
dc.contributor.authorSuh, Gee Young-
dc.contributor.authorKim, Seok Chan-
dc.date.accessioned2021-09-05T10:38:16Z-
dc.date.available2021-09-05T10:38:16Z-
dc.date.created2021-06-15-
dc.date.issued2014-03-10-
dc.identifier.issn1471-2253-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/99023-
dc.description.abstractBackground: The role of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) as a prognostic factor in patients admitted to the intensive care unit (ICU) is not yet fully established. We aimed to determine whether NT-pro-BNP is predictive of ICU mortality in a multicenter cohort of critically ill patients. Methods: A total of 1440 patients admitted to 22 ICUs ( medical, 14; surgical, six; multidisciplinary, two) in 15 tertiary or university-affiliated hospitals between July 2010 and January 2011 were assessed. Patient data, including NT-pro-BNP levels and Simplified Acute Physiology Score ( SAPS) 3 scores, were recorded prospectively in a web-based database. Results: The median age was 64 years ( range, 53-73 years), and 906 ( 62.9%) patients were male. The median NT-pro-BNP level was 341 pg/mL ( 104-1,637 pg/mL), and the median SAPS 3 score was 57 ( range, 47-69). The ICU mortality rate was 18.9%, and hospital mortality was 24.5%. Hospital survivors showed significantly lower NT-pro-BNP values than nonsurvivors ( 245 pg/mL [ range, 82-1,053 pg/mL] vs. 875 pg/mL [ 241-5,000 pg/mL], respectively; p <0.001). In prediction of hospital mortality, the area under the curve (AUC) for NT-pro-BNP was 0.67 ( 95% confidence interval [CI], 0.64-0.70) and SAPS 3 score was 0.83 ( 95% CI, 0.81-0.85). AUC increment by adding NT-pro-BNP is minimal and likely no different to SAPS 3 alone. Conclusions: The NT-pro-BNP level was more elevated in nonsurvivors in a multicenter cohort of critically ill patients. However, there was little additional prognostic power when adding NT-pro-BNP to SAPS 3 score.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherBIOMED CENTRAL LTD-
dc.subjectCRITICALLY-ILL PATIENTS-
dc.subjectADMISSION SCORE-
dc.subjectVALIDATION-
dc.subjectCUSTOMIZATION-
dc.subjectPOPULATION-
dc.subjectPREDICTOR-
dc.subjectMORTALITY-
dc.subjectFAILURE-
dc.subjectCOHORT-
dc.subjectHEART-
dc.titleUsefulness of N-terminal pro-B-type natriuretic peptide in patients admitted to the intensive care unit: a multicenter prospective observational study-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Je Hyeong-
dc.identifier.doi10.1186/1471-2253-14-16-
dc.identifier.scopusid2-s2.0-84897941761-
dc.identifier.wosid000334455400001-
dc.identifier.bibliographicCitationBMC ANESTHESIOLOGY, v.14-
dc.relation.isPartOfBMC ANESTHESIOLOGY-
dc.citation.titleBMC ANESTHESIOLOGY-
dc.citation.volume14-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaAnesthesiology-
dc.relation.journalWebOfScienceCategoryAnesthesiology-
dc.subject.keywordPlusCRITICALLY-ILL PATIENTS-
dc.subject.keywordPlusADMISSION SCORE-
dc.subject.keywordPlusVALIDATION-
dc.subject.keywordPlusCUSTOMIZATION-
dc.subject.keywordPlusPOPULATION-
dc.subject.keywordPlusPREDICTOR-
dc.subject.keywordPlusMORTALITY-
dc.subject.keywordPlusFAILURE-
dc.subject.keywordPlusCOHORT-
dc.subject.keywordPlusHEART-
dc.subject.keywordAuthorN-terminal pro-B-type natriuretic peptide-
dc.subject.keywordAuthorIntensive care unit-
dc.subject.keywordAuthorCritical care-
dc.subject.keywordAuthorPrognosis-
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