Phosphorylation of LSD1 by PKC alpha Is Crucial for Circadian Rhythmicity and Phase Resetting
DC Field | Value | Language |
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dc.contributor.author | Nam, Hye Jin | - |
dc.contributor.author | Boo, Kyungjin | - |
dc.contributor.author | Kim, Dongha | - |
dc.contributor.author | Han, Dong-Hee | - |
dc.contributor.author | Choe, Han Kyoung | - |
dc.contributor.author | Kim, Chang Rok | - |
dc.contributor.author | Sun, Woong | - |
dc.contributor.author | Kim, Hyun | - |
dc.contributor.author | Kim, Kyungjin | - |
dc.contributor.author | Lee, Ho | - |
dc.contributor.author | Metzger, Eric | - |
dc.contributor.author | Schuele, Roland | - |
dc.contributor.author | Yoo, Seung-Hee | - |
dc.contributor.author | Takahashi, Joseph S. | - |
dc.contributor.author | Cho, Sehyung | - |
dc.contributor.author | Son, Gi Hoon | - |
dc.contributor.author | Baek, Sung Hee | - |
dc.date.accessioned | 2021-09-05T10:40:19Z | - |
dc.date.available | 2021-09-05T10:40:19Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-03-06 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99029 | - |
dc.description.abstract | The circadian clock is a self-sustaining oscillator that controls daily rhythms. For the proper circadian gene expression, dynamic changes in chromatin structure are important. Although chromatin modifiers have been shown to play a role in circadian gene expression, the in vivo role of circadian signal-modulated chromatin modifiers at an organism level remains to be elucidated. Here, we provide evidence that the lysine-specific demethylase 1 (LSD1) is phosphorylated by protein kinase C alpha (PKC alpha) in a circadian manner and the phosphorylated LSD1 forms a complex with CLOCK:BMAL1 to facilitate E-box-mediated transcriptional activation. Knockin mice bearing phosphorylation-defective Lsd1(SA/SA) alleles exhibited altered circadian rhythms in locomotor behavior with attenuation of rhythmic expression of core clock genes and impaired phase resetting of circadian clock. These data demonstrate that LSD1 is a key component of the molecular circadian oscillator, which plays a pivotal role in rhythmicity and phase resetting of the circadian clock. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.subject | STRUCTURAL BASIS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | CLOCK | - |
dc.subject | PROTEIN | - |
dc.subject | CHROMATIN | - |
dc.subject | NUCLEUS | - |
dc.subject | MPER2 | - |
dc.subject | MOUSE | - |
dc.subject | DEMETHYLATION | - |
dc.subject | TRANSCRIPTION | - |
dc.title | Phosphorylation of LSD1 by PKC alpha Is Crucial for Circadian Rhythmicity and Phase Resetting | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sun, Woong | - |
dc.contributor.affiliatedAuthor | Kim, Hyun | - |
dc.contributor.affiliatedAuthor | Son, Gi Hoon | - |
dc.identifier.doi | 10.1016/j.molcel.2014.01.028 | - |
dc.identifier.scopusid | 2-s2.0-84896715662 | - |
dc.identifier.wosid | 000332531600011 | - |
dc.identifier.bibliographicCitation | MOLECULAR CELL, v.53, no.5, pp.791 - 805 | - |
dc.relation.isPartOf | MOLECULAR CELL | - |
dc.citation.title | MOLECULAR CELL | - |
dc.citation.volume | 53 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 791 | - |
dc.citation.endPage | 805 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | STRUCTURAL BASIS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CLOCK | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CHROMATIN | - |
dc.subject.keywordPlus | NUCLEUS | - |
dc.subject.keywordPlus | MPER2 | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | DEMETHYLATION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
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