Vitamin D Levels in Children and Adolescents with Antiepileptic Drug Treatment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Baek, Jung-Hyun | - |
dc.contributor.author | Seo, Young-Ho | - |
dc.contributor.author | Kim, Gun-Ha | - |
dc.contributor.author | Kim, Mi-Kyung | - |
dc.contributor.author | Eun, Baik-Lin | - |
dc.date.accessioned | 2021-09-05T10:43:31Z | - |
dc.date.available | 2021-09-05T10:43:31Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-03-01 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99051 | - |
dc.description.abstract | Purpose: This study was to evaluate the relationship of 25(OH)D-3 levels with anticonvulsant use and other possible factors in epileptic children and adolescents. Materials and Methods: We studied 143 patients with epilepsy (90 boys, 53 girls; 11.21+/-4.49 years), who had been treated with anticonvulsants for more than 1 year. Patients who had taken multiple vitamins before the blood test and those who have the limitation of physical activity (wheelchair-bound) were excluded from the study. We evaluated the difference in vitamin D status according to the type and number of anticonvulsants taken and other factors such as gender, age, intelligence and seizure variables. Results: For patients with mental retardation or developmental delay, 25(OH)D-3 levels were lower than the levels in patients with normal intelligence quotient levels (p=0.03). 25(OH)D-3 levels were lower in patients who had taken anticonvulsants for more than 2 years as compared to those who had taken them for less than 2 years (p=0.03). Those taking oxcarbazepine had significantly lower vitamin D levels than patients taking valproic acid (p=0.01). However, no effects of number of anticonvulsants taken were detectable. More than two-thirds of the patients were diagnosed with osteopenia or osteoporosis in patients showing either vitamin D insufficiency or deficiency. Conclusion: The possibility of vitamin D deficiency can be considered in pediatric patients taking anticonvulsants if they have mental retardation or developmental delay or if they have been taking anticonvalsants for more than 2 years or taking hepatic enzyme inducing drugs. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | YONSEI UNIV COLL MEDICINE | - |
dc.subject | BONE TURNOVER | - |
dc.subject | D DEFICIENCY | - |
dc.subject | EPILEPSY | - |
dc.subject | HEALTH | - |
dc.subject | OXCARBAZEPINE | - |
dc.subject | PEOPLE | - |
dc.subject | RISK | - |
dc.title | Vitamin D Levels in Children and Adolescents with Antiepileptic Drug Treatment | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Gun-Ha | - |
dc.contributor.affiliatedAuthor | Eun, Baik-Lin | - |
dc.identifier.doi | 10.3349/ymj.2014.55.2.417 | - |
dc.identifier.scopusid | 2-s2.0-84894274305 | - |
dc.identifier.wosid | 000331916800019 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, v.55, no.2, pp.417 - 421 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.citation.title | YONSEI MEDICAL JOURNAL | - |
dc.citation.volume | 55 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 417 | - |
dc.citation.endPage | 421 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001851887 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | BONE TURNOVER | - |
dc.subject.keywordPlus | D DEFICIENCY | - |
dc.subject.keywordPlus | EPILEPSY | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | OXCARBAZEPINE | - |
dc.subject.keywordPlus | PEOPLE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Vitamin D | - |
dc.subject.keywordAuthor | epilepsy | - |
dc.subject.keywordAuthor | anticonvulsants | - |
dc.subject.keywordAuthor | developmental disabilities | - |
dc.subject.keywordAuthor | intellectual disability | - |
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