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Vitamin D Levels in Children and Adolescents with Antiepileptic Drug Treatment

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dc.contributor.authorBaek, Jung-Hyun-
dc.contributor.authorSeo, Young-Ho-
dc.contributor.authorKim, Gun-Ha-
dc.contributor.authorKim, Mi-Kyung-
dc.contributor.authorEun, Baik-Lin-
dc.date.accessioned2021-09-05T10:43:31Z-
dc.date.available2021-09-05T10:43:31Z-
dc.date.created2021-06-15-
dc.date.issued2014-03-01-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/99051-
dc.description.abstractPurpose: This study was to evaluate the relationship of 25(OH)D-3 levels with anticonvulsant use and other possible factors in epileptic children and adolescents. Materials and Methods: We studied 143 patients with epilepsy (90 boys, 53 girls; 11.21+/-4.49 years), who had been treated with anticonvulsants for more than 1 year. Patients who had taken multiple vitamins before the blood test and those who have the limitation of physical activity (wheelchair-bound) were excluded from the study. We evaluated the difference in vitamin D status according to the type and number of anticonvulsants taken and other factors such as gender, age, intelligence and seizure variables. Results: For patients with mental retardation or developmental delay, 25(OH)D-3 levels were lower than the levels in patients with normal intelligence quotient levels (p=0.03). 25(OH)D-3 levels were lower in patients who had taken anticonvulsants for more than 2 years as compared to those who had taken them for less than 2 years (p=0.03). Those taking oxcarbazepine had significantly lower vitamin D levels than patients taking valproic acid (p=0.01). However, no effects of number of anticonvulsants taken were detectable. More than two-thirds of the patients were diagnosed with osteopenia or osteoporosis in patients showing either vitamin D insufficiency or deficiency. Conclusion: The possibility of vitamin D deficiency can be considered in pediatric patients taking anticonvulsants if they have mental retardation or developmental delay or if they have been taking anticonvalsants for more than 2 years or taking hepatic enzyme inducing drugs.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherYONSEI UNIV COLL MEDICINE-
dc.subjectBONE TURNOVER-
dc.subjectD DEFICIENCY-
dc.subjectEPILEPSY-
dc.subjectHEALTH-
dc.subjectOXCARBAZEPINE-
dc.subjectPEOPLE-
dc.subjectRISK-
dc.titleVitamin D Levels in Children and Adolescents with Antiepileptic Drug Treatment-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Gun-Ha-
dc.contributor.affiliatedAuthorEun, Baik-Lin-
dc.identifier.doi10.3349/ymj.2014.55.2.417-
dc.identifier.scopusid2-s2.0-84894274305-
dc.identifier.wosid000331916800019-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, v.55, no.2, pp.417 - 421-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.citation.titleYONSEI MEDICAL JOURNAL-
dc.citation.volume55-
dc.citation.number2-
dc.citation.startPage417-
dc.citation.endPage421-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.identifier.kciidART001851887-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaGeneral & Internal Medicine-
dc.relation.journalWebOfScienceCategoryMedicine, General & Internal-
dc.subject.keywordPlusBONE TURNOVER-
dc.subject.keywordPlusD DEFICIENCY-
dc.subject.keywordPlusEPILEPSY-
dc.subject.keywordPlusHEALTH-
dc.subject.keywordPlusOXCARBAZEPINE-
dc.subject.keywordPlusPEOPLE-
dc.subject.keywordPlusRISK-
dc.subject.keywordAuthorVitamin D-
dc.subject.keywordAuthorepilepsy-
dc.subject.keywordAuthoranticonvulsants-
dc.subject.keywordAuthordevelopmental disabilities-
dc.subject.keywordAuthorintellectual disability-
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