Antihyperlipidemic effects of stilbenoids isolated from Morus alba in rats fed a high-cholesterol diet
DC Field | Value | Language |
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dc.contributor.author | Jo, Sung-Pil | - |
dc.contributor.author | Kim, Jeong-Keun | - |
dc.contributor.author | Lim, Young-Hee | - |
dc.date.accessioned | 2021-09-05T10:49:50Z | - |
dc.date.available | 2021-09-05T10:49:50Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99094 | - |
dc.description.abstract | Mulberroside A (MUL) was purified from an ethanol extract of Morus alba root, and oxyresveratrol (OXY) was produced by enzymatic conversion of MUL. Normal rats, Triton WR-1339-induced hyperlipidemic rats, and high-cholesterol diet (HCD)-induced hyperlipidemic rats were orally treated with MUL or OXY (1-5 mg/kg/day). MUL and OXY were administered 1 h prior to concomitant treatment with Triton WR-1339 for a further 24 h, whereas the drugs were administered concurrently with HCD for 4 weeks. Oral MUL and OXY pre-treatment vs. water pre-treatment of Triton WR-1339-induced hyperlipidemic rats significantly (p < 0.05) reduced the levels of serum lipids in a dose-dependent manner, while high-density lipoprotein cholesterol (HDL-C, or "good" cholesterol) levels were increased. Oral MUL and OXY treatment of HCD-fed rats also showed a significant (p < 0.05) dose-dependent decrease in serum lipids, coronary artery risk index (CRI), and atherogenic index (Al), but not HDL-C. Furthermore, MUL and OXY treatment of HCD-induced hyperlipidemic rats demonstrated a significant dose-dependent improvement in the histological features of hepatic fatty degeneration. Aspartate aminotransferase and alanine aminotransferase values in OXY-treated normal rats were not significantly different from those in water-treated control rats. These results indicate that MUL and OXY might be developed as novel anti-hyperlipidemic agents. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | HIGH-FAT-DIET | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | ROOT BARK | - |
dc.subject | ACID | - |
dc.subject | HYPERCHOLESTEROLEMIA | - |
dc.subject | DYSLIPIDEMIA | - |
dc.subject | OXYRESVERATROL | - |
dc.subject | RESVERATROL | - |
dc.subject | ANTIOBESITY | - |
dc.subject | STATINS | - |
dc.title | Antihyperlipidemic effects of stilbenoids isolated from Morus alba in rats fed a high-cholesterol diet | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Young-Hee | - |
dc.identifier.doi | 10.1016/j.fct.2013.12.040 | - |
dc.identifier.scopusid | 2-s2.0-84892889356 | - |
dc.identifier.wosid | 000332500500027 | - |
dc.identifier.bibliographicCitation | FOOD AND CHEMICAL TOXICOLOGY, v.65, pp.213 - 218 | - |
dc.relation.isPartOf | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.title | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.volume | 65 | - |
dc.citation.startPage | 213 | - |
dc.citation.endPage | 218 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | HIGH-FAT-DIET | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | ROOT BARK | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | HYPERCHOLESTEROLEMIA | - |
dc.subject.keywordPlus | DYSLIPIDEMIA | - |
dc.subject.keywordPlus | OXYRESVERATROL | - |
dc.subject.keywordPlus | RESVERATROL | - |
dc.subject.keywordPlus | ANTIOBESITY | - |
dc.subject.keywordPlus | STATINS | - |
dc.subject.keywordAuthor | Antihyperlipidemic activity | - |
dc.subject.keywordAuthor | Stilbenoids | - |
dc.subject.keywordAuthor | High-cholesterol diet | - |
dc.subject.keywordAuthor | Atherogenic index | - |
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