A Web- Based Nomogram Predicting Para- aortic Nodal Metastasis in Incompletely Staged Patients With Endometrial Cancer
DC Field | Value | Language |
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dc.contributor.author | Kang, Sokbom | - |
dc.contributor.author | Lee, Jong-Min | - |
dc.contributor.author | Lee, Jae-Kwan | - |
dc.contributor.author | Kim, Jae-Weon | - |
dc.contributor.author | Cho, Chi-Heum | - |
dc.contributor.author | Kim, Seok-Mo | - |
dc.contributor.author | Park, Sang-Yoon | - |
dc.contributor.author | Park, Chan-Yong | - |
dc.contributor.author | Kim, Ki-Tae | - |
dc.date.accessioned | 2021-09-05T10:57:27Z | - |
dc.date.available | 2021-09-05T10:57:27Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 1048-891X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99119 | - |
dc.description.abstract | Objective The purpose of this study is to develop a Web-based nomogram for predicting the individualized risk of para-aortic nodal metastasis in incompletely staged patients with endometrial cancer. Methods From 8 institutions, the medical records of 397 patients who underwent pelvic and para-aortic lymphadenectomy as a surgical staging procedure were retrospectively reviewed. A multivariate logistic regression model was created and internally validated by rigorous bootstrap resampling methods. Finally, the model was transformed into a user-friendly Web-based nomogram (http://www.kgog.org/nomogram/empa001.html). Results The rate of para-aortic nodal metastasis was 14.4% (57/397 patients). Using a stepwise variable selection, 4 variables including deep myometrial invasion, non-endometrioid subtype, lymphovascular space invasion, and log-transformed CA-125 levels were finally adopted. After 1000 repetitions of bootstrapping, all of these 4 variables retained a significant association with para-aortic nodal metastasis in the multivariate analysisdeep myometrial invasion (P = 0.001), non-endometrioid histologic subtype (P = 0.034), lymphovascular space invasion (P = 0.003), and log-transformed serum CA-125 levels (P = 0.004). The model showed good discrimination (C statistics = 0.87; 95% confidence interval, 0.82-0.92) and accurate calibration (Hosmer-Lemeshow P = 0.74). Conclusions This nomogram showed good performance in predicting para-aortic metastasis in patients with endometrial cancer. The tool may be useful in determining the extent of lymphadenectomy after incomplete surgery. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | UTERINE-CANCER | - |
dc.subject | RISK | - |
dc.subject | LYMPHADENECTOMY | - |
dc.subject | STATISTICS | - |
dc.subject | CARCINOMA | - |
dc.subject | MODELS | - |
dc.subject | GRADE | - |
dc.title | A Web- Based Nomogram Predicting Para- aortic Nodal Metastasis in Incompletely Staged Patients With Endometrial Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Kwan | - |
dc.identifier.doi | 10.1097/IGC.0000000000000090 | - |
dc.identifier.scopusid | 2-s2.0-84900404333 | - |
dc.identifier.wosid | 000332519000019 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, v.24, no.3, pp.513 - 519 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | - |
dc.citation.title | INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | - |
dc.citation.volume | 24 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 513 | - |
dc.citation.endPage | 519 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.subject.keywordPlus | UTERINE-CANCER | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | LYMPHADENECTOMY | - |
dc.subject.keywordPlus | STATISTICS | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | MODELS | - |
dc.subject.keywordPlus | GRADE | - |
dc.subject.keywordAuthor | Endometrial cancer | - |
dc.subject.keywordAuthor | Lymph node | - |
dc.subject.keywordAuthor | Lymphadenectomy | - |
dc.subject.keywordAuthor | Metastasis | - |
dc.subject.keywordAuthor | Para-aortic | - |
dc.subject.keywordAuthor | Staging | - |
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