Urine Liver-Type Fatty Acid-Binding Protein Predicts Graft Outcome up to 2 Years After Kidney Transplantation
DC Field | Value | Language |
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dc.contributor.author | Yang, J. | - |
dc.contributor.author | Choi, H. M. | - |
dc.contributor.author | Seo, M. Y. | - |
dc.contributor.author | Lee, J. Y. | - |
dc.contributor.author | Kim, K. | - |
dc.contributor.author | Jun, H. | - |
dc.contributor.author | Jung, C. W. | - |
dc.contributor.author | Park, K. T. | - |
dc.contributor.author | Kim, M. -G. | - |
dc.contributor.author | Jo, S. -K. | - |
dc.contributor.author | Cho, W. | - |
dc.contributor.author | Kim, H. K. | - |
dc.date.accessioned | 2021-09-05T10:58:26Z | - |
dc.date.available | 2021-09-05T10:58:26Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 0041-1345 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99126 | - |
dc.description.abstract | Background. Several new biomarkers for the detection of early tubular injury have been investigated in kidney transplant recipients. We recently identified day 2 urinary neutrophil gelatinase-associated lipocalin (NGAL) as a predictor of slow graft function and adverse 1-year outcome. In the present study, we further investigated the value of urinary NGAL and liver-type fatty acid binding protein (L-FABP) for predicting long-term graft outcomes up to 2 years. Methods. This study was a single-center, prospective observational study. Serial urinary NGAL and L-FABP levels at 0 hours, 2 days, and 6 days after kidney transplantation (KT) were measured, and the clinical data were assessed during the 2-year period after KT. Results. During the 2-year follow-up period, 13 (18.8%), 5 (7.2%), and 4 (5.8%) patients were diagnosed with acute T-cell-mediated rejection, acute antibody-mediated rejection (AMR) and chronic AMR, respectively. In addition, 10 patients (14.3%) developed calcineurin inhibitor toxicity and 6 (8.7%) developed BK viremia. The mean estimated glomerular filtration rates (eGFR) at 1 and 2 years after KT were 65.1 +/- 19.1 and 58.5 +/- 22 6 mL/min/1.73 m(2), respectively, When poor long-term graft function was defined as eGFR of less than 50 mL/min/1.73 m(2) at 2 years, elderly donors, acute rejection, and high 0-hour urinary L-FABP levels were significant risk factors. Furthermore, in rejection-free patients, L-FABP was strongly associated with poor long-term graft function (P = .006). Multivariate logistic regression analysis showed that high 0-hour L-FABP (P = .015) and acute rejection (P = .006) were independent factors predicting poor long-term graft function. Receiver operating characteristic analysis showed that the area under the curve for urinary L-FABP was 0.692 (P = .036). Conclusions. Our results suggest that urinary L-FABP may be a useful predictor of adverse long-term outcomes in KT patients. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | GELATINASE-ASSOCIATED LIPOCALIN | - |
dc.subject | ACUTE ISCHEMIC-INJURY | - |
dc.subject | RENAL-TRANSPLANTATION | - |
dc.subject | ADVERSE OUTCOMES | - |
dc.subject | CARDIAC-SURGERY | - |
dc.subject | BIOMARKER | - |
dc.subject | NGAL | - |
dc.subject | NEPHROPATHY | - |
dc.subject | DIALYSIS | - |
dc.subject | DISEASE | - |
dc.title | Urine Liver-Type Fatty Acid-Binding Protein Predicts Graft Outcome up to 2 Years After Kidney Transplantation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, C. W. | - |
dc.contributor.affiliatedAuthor | Kim, M. -G. | - |
dc.contributor.affiliatedAuthor | Cho, W. | - |
dc.identifier.doi | 10.1016/j.transproceed.2013.11.130 | - |
dc.identifier.wosid | 000333572100019 | - |
dc.identifier.bibliographicCitation | TRANSPLANTATION PROCEEDINGS, v.46, no.2, pp.376 - 380 | - |
dc.relation.isPartOf | TRANSPLANTATION PROCEEDINGS | - |
dc.citation.title | TRANSPLANTATION PROCEEDINGS | - |
dc.citation.volume | 46 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 376 | - |
dc.citation.endPage | 380 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.subject.keywordPlus | GELATINASE-ASSOCIATED LIPOCALIN | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-INJURY | - |
dc.subject.keywordPlus | RENAL-TRANSPLANTATION | - |
dc.subject.keywordPlus | ADVERSE OUTCOMES | - |
dc.subject.keywordPlus | CARDIAC-SURGERY | - |
dc.subject.keywordPlus | BIOMARKER | - |
dc.subject.keywordPlus | NGAL | - |
dc.subject.keywordPlus | NEPHROPATHY | - |
dc.subject.keywordPlus | DIALYSIS | - |
dc.subject.keywordPlus | DISEASE | - |
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