IgA(+)plasma cells in murine intestinal lamina propria as a positive regulator of T-reg differentiation
DC Field | Value | Language |
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dc.contributor.author | Kim, Myun Soo | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.date.accessioned | 2021-09-05T10:59:29Z | - |
dc.date.available | 2021-09-05T10:59:29Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99133 | - |
dc.description.abstract | IgA(+) plasma cells from murine small intestinal lamina propria induce Foxp3 expression in CD4(+)CD25(-) T cells via TGF- and retinoic acid. Continuous exposure to commensal bacteria gives rise to a complex intestinal immune system that maintains local tolerance, which requires Foxp3-expressing T-reg. Recently, the regulation of T-FH function by plasma cells has been reported, but effects of intestinal LP-PCs, one of the richest plasma cells in the body, on T cell differentiation have not been studied. Here, we investigated whether IgA(+) LP-PCs from murine small intestines had effects on T cell differentiation. Surprisingly, when IgA(+) LP-PCs were cocultured with CD4(+) T cells, Foxp3 expression was increased significantly in CD4(+)CD25(-) T cells. Results using the Transwell coculture system revealed that soluble factors from LP-PCs, TGF-, and RA were involved in the induction of Foxp3 expression. Furthermore, Foxp3(+)CD25(-) T cells were decreased in PP after intestinal depletion of plasma cells. In addition, intestinal colony transfer from SPF to germ-free mice was demonstrated to generate IgA(+) LP-PCs and Foxp3(+) T cells with meaningful correlation in LP. We report for the first time that IgA(+) LP-PCs induce Foxp3 expression in T cells through TGF- and RA. LP-PCs generated by commensal bacteria may play a crucial role in intestinal immunity through the induction of T-reg, as well as IgA production. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | PLASMA-CELLS | - |
dc.subject | RETINOIC ACID | - |
dc.subject | IGA | - |
dc.subject | EXPRESSION | - |
dc.subject | FOXP3 | - |
dc.subject | INTERLEUKIN-10 | - |
dc.subject | MACROPHAGES | - |
dc.subject | RECEPTORS | - |
dc.subject | INDUCTION | - |
dc.title | IgA(+)plasma cells in murine intestinal lamina propria as a positive regulator of T-reg differentiation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.1189/jlb.0613310 | - |
dc.identifier.scopusid | 2-s2.0-84899477465 | - |
dc.identifier.wosid | 000335324400010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF LEUKOCYTE BIOLOGY, v.95, no.3, pp.461 - 469 | - |
dc.relation.isPartOf | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.citation.title | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.citation.volume | 95 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 461 | - |
dc.citation.endPage | 469 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | PLASMA-CELLS | - |
dc.subject.keywordPlus | RETINOIC ACID | - |
dc.subject.keywordPlus | IGA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | FOXP3 | - |
dc.subject.keywordPlus | INTERLEUKIN-10 | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | Foxp3 | - |
dc.subject.keywordAuthor | regulatory T cell | - |
dc.subject.keywordAuthor | TGF- | - |
dc.subject.keywordAuthor | retinoic acid | - |
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