The foregut theory as a possible mechanism of action for the remission of type 2 diabetes in low body mass index patients undergoing subtotal gastrectomy for gastric cancer
DC Field | Value | Language |
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dc.contributor.author | Kwon, Yeongkeun | - |
dc.contributor.author | Abdemur, Abraham | - |
dc.contributor.author | Lo Menzo, Emanuele | - |
dc.contributor.author | Park, Sungsoo | - |
dc.contributor.author | Szomstein, Samuel | - |
dc.contributor.author | Rosenthal, Raul J. | - |
dc.date.accessioned | 2021-09-05T11:15:48Z | - |
dc.date.available | 2021-09-05T11:15:48Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 1550-7289 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99242 | - |
dc.description.abstract | Background: The question of whether pure metabolic surgery could be used in nonobese patients with type 2 diabetes has been considered. The objective of this study was to assess the comparative effects of the Billroth I (BI) and Billroth II (BII) reconstruction methods on remission of type 2 diabetes in nonobese patients undergoing subtotal gastrectomy for cancer. Methods: The charts of 404 patients who underwent radical subtotal gastrectomy for cancer between January 2008 and December 2010 were retrospectively reviewed. From these patients, 49 with type 2 diabetes were included in this study. Diabetes remission rates, the percentage change in fasting plasma glucose levels, glycated hemoglobin levels, body mass index, and fasting total cholesterol levels at 2 years were observed. Outcomes were compared using propensity scores and inverse probability-weighting adjustment that reduced treatment-selection bias. Covariate-adjusted logistic regression models were assessed. Results: The 2-year diabetes remission rate for the 23 patients who underwent BI reconstruction was 39.1%, compared with 50.0% for the 26 patients who underwent BB reconstruction. At 2 years, the BII group showed lower glycated hemoglobin levels (BI, 6.4%; BII, 6.1%; P = .003) and had greater percent reductions in their average glycated hemoglobin levels from baseline (BI, -11.6%; BII, -14.5%; P = .043). BII reconstruction was significantly associated with an increased diabetes remission rate (odds ratio, 3.22; 95% confidence interval, 1.05-9.83) in covariate-adjusted logistic regression analysis. Conclusions: These propensity score-adjusted analyses of patients who had undergone subtotal gastrectomy indicated that BII reconstruction was associated with increased diabetes remission compared with BI reconstruction during the 2-year follow-up period. This study suggests the possibility of employing the surgical duodenal switch for the treatment of nonobese type 2 diabetes patients. (C) 2014 American Society for Metabolic and Bariatric Surgery. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | BARIATRIC SURGERY | - |
dc.subject | SLEEVE GASTRECTOMY | - |
dc.subject | WEIGHT-LOSS | - |
dc.subject | INSULIN-SECRETION | - |
dc.subject | METABOLIC SURGERY | - |
dc.subject | BYPASS-SURGERY | - |
dc.subject | LIFE-STYLE | - |
dc.subject | MELLITUS | - |
dc.subject | GLUCOSE | - |
dc.subject | RECOVERY | - |
dc.title | The foregut theory as a possible mechanism of action for the remission of type 2 diabetes in low body mass index patients undergoing subtotal gastrectomy for gastric cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Sungsoo | - |
dc.identifier.doi | 10.1016/j.soard.2013.09.013 | - |
dc.identifier.scopusid | 2-s2.0-84897439876 | - |
dc.identifier.wosid | 000334647000008 | - |
dc.identifier.bibliographicCitation | SURGERY FOR OBESITY AND RELATED DISEASES, v.10, no.2, pp.235 - 242 | - |
dc.relation.isPartOf | SURGERY FOR OBESITY AND RELATED DISEASES | - |
dc.citation.title | SURGERY FOR OBESITY AND RELATED DISEASES | - |
dc.citation.volume | 10 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 235 | - |
dc.citation.endPage | 242 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | BARIATRIC SURGERY | - |
dc.subject.keywordPlus | SLEEVE GASTRECTOMY | - |
dc.subject.keywordPlus | WEIGHT-LOSS | - |
dc.subject.keywordPlus | INSULIN-SECRETION | - |
dc.subject.keywordPlus | METABOLIC SURGERY | - |
dc.subject.keywordPlus | BYPASS-SURGERY | - |
dc.subject.keywordPlus | LIFE-STYLE | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | RECOVERY | - |
dc.subject.keywordAuthor | Metabolic surgery | - |
dc.subject.keywordAuthor | Subtotal gastrectomy | - |
dc.subject.keywordAuthor | Billroth | - |
dc.subject.keywordAuthor | Type 2 diabetes | - |
dc.subject.keywordAuthor | Gastric cancer | - |
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