Characterization of Gp41 Polymorphisms in the Fusion Peptide Domain and T-20 (Enfuvirtide) Resistance-Associated Regions in Korean HIV-1 Isolates
DC Field | Value | Language |
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dc.contributor.author | Jang, Dai-Ho | - |
dc.contributor.author | Yoon, Cheol-Hee | - |
dc.contributor.author | Choi, Byeong-Sun | - |
dc.contributor.author | Chung, Yoon-Seok | - |
dc.contributor.author | Kim, Hye-Young | - |
dc.contributor.author | Chi, Sung-Gil | - |
dc.contributor.author | Kim, Sung Soon | - |
dc.date.accessioned | 2021-09-05T11:16:40Z | - |
dc.date.available | 2021-09-05T11:16:40Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99249 | - |
dc.description.abstract | HIV-1 gp41 is an envelope protein that plays an essential role in virus entry. The mutation of gp41 affects HIV-1 entry and susceptibility to the fusion inhibitor T-20. Therefore, we analyzed the natural polymorphism of gp41 of 163 HIV-1 isolates from T-20-naive Koreans infected with HIV-1. This study of gp41 polymorphisms showed that insertions in the fourth threonine (74.8%) and L7M substitutions (85.3%) were more frequent in the fusion peptide motif in Korean HIV-1 isolates compared with those from other countries. Minor T-20 resistance mutations such as L45M (1.2%), N126K (1.2%), and E137K (6.7%) were detected, but the critical T-20 resistance mutations were not detected in the gp41 HR1 and HR2 regions. In addition, the N42S mutation (12.9%) associated with T-20 hypersusceptibility was detected at a high frequency. These results may serve as useful data for studies considering T-20 for use in the development of a more effective anti-retroviral treatment in Korea. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.subject | TYPE-1 GP41 | - |
dc.subject | MUTATIONS | - |
dc.subject | SUBSTITUTIONS | - |
dc.subject | EVOLUTION | - |
dc.subject | THERAPY | - |
dc.subject | IMPACT | - |
dc.subject | HR1 | - |
dc.subject | MEN | - |
dc.title | Characterization of Gp41 Polymorphisms in the Fusion Peptide Domain and T-20 (Enfuvirtide) Resistance-Associated Regions in Korean HIV-1 Isolates | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Byeong-Sun | - |
dc.contributor.affiliatedAuthor | Chi, Sung-Gil | - |
dc.identifier.doi | 10.3346/jkms.2014.29.3.456 | - |
dc.identifier.scopusid | 2-s2.0-84908364495 | - |
dc.identifier.wosid | 000333156300025 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.29, no.3, pp.456 - 459 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 29 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 456 | - |
dc.citation.endPage | 459 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001858608 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | TYPE-1 GP41 | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | SUBSTITUTIONS | - |
dc.subject.keywordPlus | EVOLUTION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | HR1 | - |
dc.subject.keywordPlus | MEN | - |
dc.subject.keywordAuthor | Fusion Inhibitor | - |
dc.subject.keywordAuthor | Fusion Peptide | - |
dc.subject.keywordAuthor | Gp41 Polymorphism | - |
dc.subject.keywordAuthor | HIV-1 Envelope Glycoprotein | - |
dc.subject.keywordAuthor | T-20 Resistance Mutation | - |
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