Complex adaptive therapeutic strategy (CATS) for cancer
- Authors
- Cho, Yong Woo; Kim, Sang Yoon; Kwon, Ick Chan; Kim, In-San
- Issue Date
- 10-2월-2014
- Publisher
- ELSEVIER
- Keywords
- Tumor heterogeneity; Complex adaptive system (CAS); Induced phenotype; Tumor network; Cancer immunotherapy; Nanoparticle
- Citation
- JOURNAL OF CONTROLLED RELEASE, v.175, pp.43 - 47
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CONTROLLED RELEASE
- Volume
- 175
- Start Page
- 43
- End Page
- 47
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/99296
- DOI
- 10.1016/j.jconrel.2013.12.017
- ISSN
- 0168-3659
- Abstract
- Tumors begin with a single cell, but as each tumor grows and evolves, it becomes a wide collection of clones that display remarkable heterogeneity in phenotypic features, which has posed a big challenge to current targeted anticancer therapy. Intra-and inter-tumoral heterogeneity is attributable in part to genetic mutations but also to adaptation and evolution of tumors to heterogeneity in tumor microenvironments. If tumors are viewed not only as a disease but also as a complex adaptive system(CAS), tumors should be treated as such and a more systemic approach is needed. Some of many tumors therapeutic strategies are discussed here from a view of a tumor as CAS, which can be collectively called a complex adaptive therapeutic strategy (CATS). The central theme of CATS is based on three intermediate concepts: i) disruption of artifacts, ii) disruption of connections, and iii) reprogramming of cancer-immune dynamics. Each strategy presented here is a piece of the puzzle for CATS. Although each piece by itself may be neither novel nor profound, an assembled puzzle could be a novel and innovative cancer therapeutic strategy. (C) 2013 Elsevier B.V. All rights reserved.
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