Underwound DNA under tension: L-DNA vs. plectoneme
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Son, Anmin | - |
dc.contributor.author | Kwon, Ah-Young | - |
dc.contributor.author | Johner, Albert | - |
dc.contributor.author | Hong, Seok-Cheol | - |
dc.contributor.author | Lee, Nam-Kyung | - |
dc.date.accessioned | 2021-09-05T11:32:36Z | - |
dc.date.available | 2021-09-05T11:32:36Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 0295-5075 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99335 | - |
dc.description.abstract | In many biological processes DNA experiences force in the pN range and torque that underwinds it. Magnetic tweezers experiments show that the superhelicity(sigma)-extension curve, the so-called bell curve, is asymmetric with respect to the inversion of sigma. We study the case of underwound DNA which was not addressed theoretically before. While the case of overwound DNA is fully explained by the formation of supercoil, the extension of underwound DNA reveals non-trivial tension dependence. We show that plectonemic coils form at moderate tension, whereas left-handed DNA, so-called "L-DNA", prevails at high tension (above approximate to 0.5 pN). In a narrow but physiologically relevant crossover range of tension, that is between 0.4 pN and 0.7 pN, extra unwinding turns are statistically distributed to either plectoneme or L-DNA. In this regime the states of a torsionally stressed DNA should be most sensitive to external mechanical stimuli. Copyright (C) EPLA, 2014 | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IOP PUBLISHING LTD | - |
dc.subject | ELASTICITY | - |
dc.subject | DENATURATION | - |
dc.subject | TRANSITION | - |
dc.subject | BUBBLES | - |
dc.subject | WALKS | - |
dc.title | Underwound DNA under tension: L-DNA vs. plectoneme | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Seok-Cheol | - |
dc.identifier.doi | 10.1209/0295-5075/105/48002 | - |
dc.identifier.scopusid | 2-s2.0-84896375345 | - |
dc.identifier.wosid | 000333016700030 | - |
dc.identifier.bibliographicCitation | EPL, v.105, no.4 | - |
dc.relation.isPartOf | EPL | - |
dc.citation.title | EPL | - |
dc.citation.volume | 105 | - |
dc.citation.number | 4 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Physics, Multidisciplinary | - |
dc.subject.keywordPlus | ELASTICITY | - |
dc.subject.keywordPlus | DENATURATION | - |
dc.subject.keywordPlus | TRANSITION | - |
dc.subject.keywordPlus | BUBBLES | - |
dc.subject.keywordPlus | WALKS | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.