Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: comparison with amyloid-positive mild cognitive impairment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ye, Byoung Seok | - |
dc.contributor.author | Seo, Sang Won | - |
dc.contributor.author | Kim, Chi Hun | - |
dc.contributor.author | Jeon, Seun | - |
dc.contributor.author | Kim, Geon Ha | - |
dc.contributor.author | Noh, Young | - |
dc.contributor.author | Cho, Hanna | - |
dc.contributor.author | Yoon, Cindy W. | - |
dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Jang, Eun Young | - |
dc.contributor.author | Lee, Jeongmin | - |
dc.contributor.author | Kim, Jung-Hyun | - |
dc.contributor.author | Chin, Juhee | - |
dc.contributor.author | Lee, Jong Min | - |
dc.contributor.author | Kim, Jeong-Hun | - |
dc.contributor.author | Seong, Joon-kyung | - |
dc.contributor.author | Kim, Chang-Hun | - |
dc.contributor.author | Choe, Yearn Seong | - |
dc.contributor.author | Lee, Kyung Han | - |
dc.contributor.author | Na, Duk L. | - |
dc.date.accessioned | 2021-09-05T11:33:44Z | - |
dc.date.available | 2021-09-05T11:33:44Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 0197-4580 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99343 | - |
dc.description.abstract | Although patients with amnestic mild cognitive impairment (aMCI) are at higher risk of developing Alzheimer's disease (AD), their pathologies could be heterogeneous. We aimed to evaluate structural changes in amyloid-negative and amyloid-positive aMCI patients. Forty-eight aMCI patients who underwent Pittsburgh compound B (PiB) positron emission tomography were recruited. They were classified as PiB (-) aMCI (N = 16) and PiB (+) (N = 32). Hippocampal shape and regional cortical thickness were compared with 41 subjects with normal cognition (NC). Relative to NC, PiB(-) aMCI exhibited hippocampal deformity in the right cornu ammonis 1, whereas PiB(+) aMCI exhibited hippocampal deformity in bilateral subiculum and cornu ammonis 1 subregions. Relative to NC, PiB(-) aMCI showed cortical thinning in the left medial prefrontal and right anterior temporal regions, whereas PiB(+) aMCI exhibited cortical thinning in bilateral medial temporal regions, temporoparietal junctions and precuneus, and prefrontal cortices. Our findings suggest that structural changes in PiB(-) aMCI might be due to several possible pathologic changes, whereas structural changes in PiB(+) aMCI reflect AD-like structural changes. (C) 2014 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | BLOOD-PRESSURE | - |
dc.subject | VASCULAR DEMENTIA | - |
dc.subject | SHAPE-ANALYSIS | - |
dc.subject | BRAIN ATROPHY | - |
dc.subject | DEPRESSION | - |
dc.subject | PATTERNS | - |
dc.subject | BETA | - |
dc.subject | DEPOSITION | - |
dc.subject | FEATURES | - |
dc.title | Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: comparison with amyloid-positive mild cognitive impairment | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seong, Joon-kyung | - |
dc.contributor.affiliatedAuthor | Kim, Chang-Hun | - |
dc.identifier.doi | 10.1016/j.neurobiolaging.2013.08.017 | - |
dc.identifier.scopusid | 2-s2.0-84887232865 | - |
dc.identifier.wosid | 000328655600003 | - |
dc.identifier.bibliographicCitation | NEUROBIOLOGY OF AGING, v.35, no.2, pp.291 - 300 | - |
dc.relation.isPartOf | NEUROBIOLOGY OF AGING | - |
dc.citation.title | NEUROBIOLOGY OF AGING | - |
dc.citation.volume | 35 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 291 | - |
dc.citation.endPage | 300 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | VASCULAR DEMENTIA | - |
dc.subject.keywordPlus | SHAPE-ANALYSIS | - |
dc.subject.keywordPlus | BRAIN ATROPHY | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | PATTERNS | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | DEPOSITION | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordAuthor | Mild cognitive impairment | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Pittsburgh compound B | - |
dc.subject.keywordAuthor | Cortical thickness | - |
dc.subject.keywordAuthor | Hippocampus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.