YAP and TAZ Regulate Skin Wound Healing
DC Field | Value | Language |
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dc.contributor.author | Lee, Min-Jung | - |
dc.contributor.author | Byun, Mi Ran | - |
dc.contributor.author | Furutani-Seiki, Makoto | - |
dc.contributor.author | Hong, Jeong-Ho | - |
dc.contributor.author | Jung, Han-Sung | - |
dc.date.accessioned | 2021-09-05T11:42:05Z | - |
dc.date.available | 2021-09-05T11:42:05Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 0022-202X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99401 | - |
dc.description.abstract | The Hippo signaling pathway regulates organ size, tissue regeneration, and stem cell self-renewal. The two key downstream transcription coactivators in this pathway, Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), mediate the major gene regulation and biological functions of the Hippo pathway. The biological functions of YAP and TAZ in many tissues are known; however, their roles in skin wound healing remain unclear. To analyze whether YAP and/or TAZ are required for cutaneous wound healing, we performed small interfering RNA (siRNA)-mediated knockdown of YAP/TAZ in full-thickness skin wounds. YAP is strongly expressed in the nucleus and cytoplasm in the epidermis and hair follicle. Interestingly, YAP is expressed in the nucleus in the dermis at 2 and 7 days after wounding. TAZ normally localizes to the cytoplasm in the dermis but is distributed in both the nucleus and cytoplasm at 1 day after wounding. The knockdown of YAP and TAZ markedly delayed the rate of wound closure and reduced the transforming growth factor-beta 1 (TGF-beta 1) expression in the wound. YAP and TAZ also modulate the expression of TGF-beta 1 signaling pathway components such as Smad-2, p21, and Smad-7. These results suggest that YAP and TAZ localization to the nucleus is required for skin wound healing. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | GROWTH-FACTOR BETA-1 | - |
dc.subject | TRANSFORMING GROWTH-FACTOR-BETA-1 | - |
dc.subject | HIPPO PATHWAY | - |
dc.subject | CONTACT INHIBITION | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | TGF-BETA | - |
dc.subject | REPAIR | - |
dc.subject | MICE | - |
dc.subject | PROLIFERATION | - |
dc.subject | DOWNSTREAM | - |
dc.title | YAP and TAZ Regulate Skin Wound Healing | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Byun, Mi Ran | - |
dc.contributor.affiliatedAuthor | Hong, Jeong-Ho | - |
dc.identifier.doi | 10.1038/jid.2013.339 | - |
dc.identifier.scopusid | 2-s2.0-84892818938 | - |
dc.identifier.wosid | 000329896000031 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INVESTIGATIVE DERMATOLOGY, v.134, no.2, pp.518 - 525 | - |
dc.relation.isPartOf | JOURNAL OF INVESTIGATIVE DERMATOLOGY | - |
dc.citation.title | JOURNAL OF INVESTIGATIVE DERMATOLOGY | - |
dc.citation.volume | 134 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 518 | - |
dc.citation.endPage | 525 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | GROWTH-FACTOR BETA-1 | - |
dc.subject.keywordPlus | TRANSFORMING GROWTH-FACTOR-BETA-1 | - |
dc.subject.keywordPlus | HIPPO PATHWAY | - |
dc.subject.keywordPlus | CONTACT INHIBITION | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | DOWNSTREAM | - |
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