Clinical Characteristics and Outcomes of Acute Hepatitis A in Korea: A Nationwide Multicenter Study
DC Field | Value | Language |
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dc.contributor.author | Kwon, So Young | - |
dc.contributor.author | Park, Sang Hoon | - |
dc.contributor.author | Yeon, Jong Eun | - |
dc.contributor.author | Jeong, Sook Hyang | - |
dc.contributor.author | Kwon, Oh Sang | - |
dc.contributor.author | Lee, Jin Woo | - |
dc.contributor.author | Kim, Hong Soo | - |
dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Kim, Young Seok | - |
dc.contributor.author | Sohn, Joo Hyun | - |
dc.contributor.author | Yim, Hyung Joon | - |
dc.contributor.author | Choi, Jong Young | - |
dc.contributor.author | Lee, Myung Seok | - |
dc.contributor.author | Kweon, Young Oh | - |
dc.contributor.author | Cheong, Jae Youn | - |
dc.contributor.author | Kim, Haak Cheoul | - |
dc.contributor.author | Lee, Heon Ju | - |
dc.contributor.author | Baik, Soon Koo | - |
dc.contributor.author | An, Hyonggin | - |
dc.contributor.author | Byun, Kwan Soo | - |
dc.date.accessioned | 2021-09-05T11:50:04Z | - |
dc.date.available | 2021-09-05T11:50:04Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99420 | - |
dc.description.abstract | The aim of this study was to investigate the clinical characteristics of acute hepatitis A during a recent outbreak in Korea. Data of patients diagnosed with acute hepatitis A from 2007 to 2009 were collected from 21 tertiary hospitals retrospectively. Their demographic, clinical, and serological characteristics and their clinical outcomes were analyzed. A total of 4,218 patients (mean age 33.3 yr) were included. The median duration of admission was 9 days. The mean of the highest ALT level was 2,963 IU/L, total bilirubin was 7.3 mg/dL, prothrombin time INR was 1.3. HBsAg was positive in 3.7%, and anti-HCV positive in 0.7%. Renal insufficiency occurred in 2.7%, hepatic failure in 0.9%, relapsing hepatitis in 0.7%, and cholestatic hepatitis in 1.9% of the patients. Nineteen patients (0.45%) died or were transplanted. Complications of renal failure or prolonged cholestasis were more frequent in patients older than 30 yr. In conclusion, most patients with acute hepatitis A recover uneventfully, however, complication rates are higher in patients older than 30 yr than younger patients. Preventive strategies including universal vaccination in infants and active immunization of hepatitis A to adult population should be considered for prevention of community-wide outbreaks of hepatitis A in Korea. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.subject | LIVER-DISEASE | - |
dc.subject | VIRUS | - |
dc.subject | FAILURE | - |
dc.subject | MANIFESTATIONS | - |
dc.subject | EPIDEMIOLOGY | - |
dc.subject | VACCINATION | - |
dc.subject | ETIOLOGY | - |
dc.subject | FEATURES | - |
dc.title | Clinical Characteristics and Outcomes of Acute Hepatitis A in Korea: A Nationwide Multicenter Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yeon, Jong Eun | - |
dc.contributor.affiliatedAuthor | Seo, Yeon Seok | - |
dc.contributor.affiliatedAuthor | Yim, Hyung Joon | - |
dc.contributor.affiliatedAuthor | An, Hyonggin | - |
dc.contributor.affiliatedAuthor | Byun, Kwan Soo | - |
dc.identifier.doi | 10.3346/jkms.2014.29.2.248 | - |
dc.identifier.scopusid | 2-s2.0-84907669521 | - |
dc.identifier.wosid | 000333154700015 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.29, no.2, pp.248 - 253 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 29 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 248 | - |
dc.citation.endPage | 253 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001849082 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | LIVER-DISEASE | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | FAILURE | - |
dc.subject.keywordPlus | MANIFESTATIONS | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | VACCINATION | - |
dc.subject.keywordPlus | ETIOLOGY | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordAuthor | Hepatitis A | - |
dc.subject.keywordAuthor | Morbidity | - |
dc.subject.keywordAuthor | Mortality | - |
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