Clinical implication of negative conversion of predicted circumferential resection margin status after preoperative chemoradiotherapy for locally advanced rectal cancer
DC Field | Value | Language |
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dc.contributor.author | Lee, Nam Kwon | - |
dc.contributor.author | Kim, Chul Yong | - |
dc.contributor.author | Park, Young Je | - |
dc.contributor.author | Yang, Dae Sik | - |
dc.contributor.author | Yoon, Won Sup | - |
dc.contributor.author | Kim, Seon Hahn | - |
dc.contributor.author | Kim, Jin | - |
dc.date.accessioned | 2021-09-05T11:54:46Z | - |
dc.date.available | 2021-09-05T11:54:46Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 0720-048X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99453 | - |
dc.description.abstract | Objective: To evaluate the prognostic implication of the negative conversion of predicted circumferential resection margin status before surgery in patients with locally advanced rectal cancer with predicted circumferential resection margin involvement. Methods: Thirty-eight patients (28 men, 10 women; median age, 61 years; age range, 39-80 years) with locally advanced rectal cancer with predicted circumferential resection margin involvement who underwent preoperative chemoradiotherapy followed by radical surgery were analyzed. Involvement of the circumferential resection margin was predicted on the basis of pre- and post-chemoradiotherapy magnetic resonance imaging. The primary endpoints were 3-year local recurrence-free survival and overall survival. Results: The median follow-up time was 41.1 months (range, 13.9-85.2 months). The negative conversion rate of predicted circumferential resection margin status after preoperative chemoradiotherapy was 65.8%. Patients who experienced negative conversion of predicted circumferential resection margin status had a significantly higher 3-year local recurrence-free survival rate (100.0% vs. 76.9%; P = 0.013), disease-free survival rate (91.7% vs. 59.3%; P = 0.023), and overall survival rate (96.0% vs. 73.8%; P = 0.016) than those who had persistent circumferential resection margin involvement. Conclusions: The negative conversion of the predicted circumferential resection margin status as predicted by magnetic resonance imaging will assist in individual risk stratification as a predictive factor for treatment response and survival before surgery. These findings may help physicians determine whether to administer more intense adjuvant chemotherapy or change the surgical plan for patients displaying resistance to preoperative chemoradiotherapy. (C) 2013 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject | MESORECTAL EXCISION | - |
dc.subject | RADIATION-THERAPY | - |
dc.subject | INVOLVEMENT | - |
dc.subject | SURVIVAL | - |
dc.subject | ADENOCARCINOMA | - |
dc.subject | RECURRENCE | - |
dc.subject | CARCINOMA | - |
dc.subject | ONCOLOGY | - |
dc.subject | INVASION | - |
dc.title | Clinical implication of negative conversion of predicted circumferential resection margin status after preoperative chemoradiotherapy for locally advanced rectal cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Nam Kwon | - |
dc.contributor.affiliatedAuthor | Kim, Chul Yong | - |
dc.contributor.affiliatedAuthor | Yang, Dae Sik | - |
dc.contributor.affiliatedAuthor | Yoon, Won Sup | - |
dc.contributor.affiliatedAuthor | Kim, Seon Hahn | - |
dc.contributor.affiliatedAuthor | Kim, Jin | - |
dc.identifier.doi | 10.1016/j.ejrad.2013.10.029 | - |
dc.identifier.scopusid | 2-s2.0-84892592338 | - |
dc.identifier.wosid | 000329632600008 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF RADIOLOGY, v.83, no.2, pp.245 - 249 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF RADIOLOGY | - |
dc.citation.title | EUROPEAN JOURNAL OF RADIOLOGY | - |
dc.citation.volume | 83 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 245 | - |
dc.citation.endPage | 249 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject.keywordPlus | MESORECTAL EXCISION | - |
dc.subject.keywordPlus | RADIATION-THERAPY | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | ONCOLOGY | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordAuthor | Rectal neoplasms | - |
dc.subject.keywordAuthor | Circumferential resection margin | - |
dc.subject.keywordAuthor | Preoperative chemoradiotherapy | - |
dc.subject.keywordAuthor | Magnetic resonance imaging | - |
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