Axin expression delays herpes simplex virus-induced autophagy and enhances viral replication in L929 cells
DC Field | Value | Language |
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dc.contributor.author | Choi, Eun-Jin | - |
dc.contributor.author | Kee, Sun-Ho | - |
dc.date.accessioned | 2021-09-05T11:58:33Z | - |
dc.date.available | 2021-09-05T11:58:33Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 0385-5600 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99475 | - |
dc.description.abstract | Axin, a negative regulator of the Wnt signaling pathway, plays a critical role in various cellular events including cell proliferation and cell death. Axin-regulated cell death affects multiple processes, including viral replication. For example, axin expression suppresses herpes simplex virus (HSV)-induced necrotic cell death and enhances viral replication. Based on these observations, this study investigated the involvement of autophagy in regulation of HSV replication and found axin expression inhibits autophagy-mediated suppression of viral replication in L929 cells. HSV infection induced autophagy in a time- and viral dose-dependent manner in control L929 cells (L-EV), whereas virus-induced autophagy was delayed in axin-expressing L929 cells (L-axin). Subsequent analysis showed that induction of autophagy by rapamycin reduced HSV replication, and that inhibiting autophagy by 3-methyladenine (3MA) and beclin-1 knockdown facilitated viral replication in L-EV cells. In addition, preventing autophagy with 3MA suppressed virus-induced cytotoxicity in L-EV cells. In contrast, HSV replication in L-axin cells was resistant to changes in autophagy. These results suggest that axin expression may render L929 cells resistant to HSV-infection induced autophagy, leading to enhanced viral replication. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | SELF-DIGESTION | - |
dc.subject | DEATH | - |
dc.subject | ACTIVATION | - |
dc.subject | APOPTOSIS | - |
dc.subject | PROTEIN | - |
dc.subject | ALPHA | - |
dc.subject | INITIATION | - |
dc.subject | INFECTION | - |
dc.subject | BECLIN | - |
dc.subject | TYPE-1 | - |
dc.title | Axin expression delays herpes simplex virus-induced autophagy and enhances viral replication in L929 cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Eun-Jin | - |
dc.contributor.affiliatedAuthor | Kee, Sun-Ho | - |
dc.identifier.doi | 10.1111/1348-0421.12123 | - |
dc.identifier.scopusid | 2-s2.0-84894032433 | - |
dc.identifier.wosid | 000333663400004 | - |
dc.identifier.bibliographicCitation | MICROBIOLOGY AND IMMUNOLOGY, v.58, no.2, pp.103 - 111 | - |
dc.relation.isPartOf | MICROBIOLOGY AND IMMUNOLOGY | - |
dc.citation.title | MICROBIOLOGY AND IMMUNOLOGY | - |
dc.citation.volume | 58 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 103 | - |
dc.citation.endPage | 111 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | SELF-DIGESTION | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | INITIATION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | BECLIN | - |
dc.subject.keywordPlus | TYPE-1 | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | axin | - |
dc.subject.keywordAuthor | herpes simplex virus | - |
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