AMPK activator-mediated inhibition of endoplasmic reticulum stress ameliorates carrageenan-induced insulin resistance through the suppression of selenoprotein P in HepG2 hepatocytes
DC Field | Value | Language |
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dc.contributor.author | Jung, Tae Woo | - |
dc.contributor.author | Lee, So Young | - |
dc.contributor.author | Hong, Ho Cheol | - |
dc.contributor.author | Choi, Hae Yoon | - |
dc.contributor.author | Yoo, Hye Jin | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.contributor.author | Choi, Kyung Mook | - |
dc.date.accessioned | 2021-09-05T12:08:47Z | - |
dc.date.available | 2021-09-05T12:08:47Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-01-25 | - |
dc.identifier.issn | 0303-7207 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99506 | - |
dc.description.abstract | Carrageenan (CGN) has been shown to cause inflammation through toll-like receptor 4, which may play an important role in insulin resistance and type 2 diabetes mellitus. Selenoprotein P (SeP) has recently been identified as a novel hepatokine that causes insulin resistance. Here, we report that treatment of HepG2 cells with CGN increased both CCAAT enhancer binding protein homologous protein (CHOP) and SeP expression. Pretreatment with 4-phenylbutyrate (4-PBA), an endoplasmic reticulum stress inhibitor, and PD98059, a c-Jun N-terminal kinase (JNK) inhibitor, reversed CGN-induced SeP expression. Moreover, both 4-PBA and knock-down of SeP improved CGN-induced insulin resistance. In addition, we found that adenosine monophosphate-activated protein kinase (AMPK) activators ameliorated CGN-induced insulin resistance in addition to suppressing CHOP and SeP expression. In conclusion, CGN-induced ER stress increased the expression of SeP through the JNK pathway, while AMPK activators ameliorated CGN-induced insulin resistance via SeP inhibition through the AMPK-mediated alleviation of ER stress in hepatocytes. (C) 2013 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | PROTEIN-KINASE | - |
dc.subject | KAPPA-B | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | INFLAMMATION | - |
dc.subject | OBESITY | - |
dc.subject | ATHEROSCLEROSIS | - |
dc.subject | PATHWAY | - |
dc.subject | BCL10 | - |
dc.title | AMPK activator-mediated inhibition of endoplasmic reticulum stress ameliorates carrageenan-induced insulin resistance through the suppression of selenoprotein P in HepG2 hepatocytes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Tae Woo | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Jin | - |
dc.contributor.affiliatedAuthor | Baik, Sei Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Kyung Mook | - |
dc.identifier.doi | 10.1016/j.mce.2013.09.013 | - |
dc.identifier.scopusid | 2-s2.0-84884939573 | - |
dc.identifier.wosid | 000330421600008 | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR ENDOCRINOLOGY, v.382, no.1, pp.66 - 73 | - |
dc.relation.isPartOf | MOLECULAR AND CELLULAR ENDOCRINOLOGY | - |
dc.citation.title | MOLECULAR AND CELLULAR ENDOCRINOLOGY | - |
dc.citation.volume | 382 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 66 | - |
dc.citation.endPage | 73 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | BCL10 | - |
dc.subject.keywordAuthor | Selenoprotein P | - |
dc.subject.keywordAuthor | Insulin resistance | - |
dc.subject.keywordAuthor | Hepatokine | - |
dc.subject.keywordAuthor | AMPK | - |
dc.subject.keywordAuthor | ER stress | - |
dc.subject.keywordAuthor | Salsalate | - |
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