Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes
DC Field | Value | Language |
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dc.contributor.author | Ha, Dae Chul | - |
dc.contributor.author | Lee, Ha Young | - |
dc.contributor.author | Son, Yeo Won | - |
dc.contributor.author | Yuk, Soon Hong | - |
dc.contributor.author | Choi, Youn Woong | - |
dc.contributor.author | Kwak, Byung Kook | - |
dc.contributor.author | Shin, Byung Cheol | - |
dc.contributor.author | Cho, Cheong-Weon | - |
dc.contributor.author | Cho, Sun Hang | - |
dc.date.accessioned | 2021-09-05T12:16:09Z | - |
dc.date.available | 2021-09-05T12:16:09Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-01-18 | - |
dc.identifier.issn | 1931-7573 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99524 | - |
dc.description.abstract | The purpose of this study was to synthesize biocompatible poly(2-hydroxyethyl aspartamide)-C-16-iron oxide (PHEA-C-16-iron oxide) nanoparticles and to evaluate their efficacy as a contrast agent for magnetic resonance imaging of lymph nodes. The PHEA-C-16-iron oxide nanoparticles were synthesized by coprecipitation method. The core size of the PHEA-C-16-iron oxide nanoparticles was about 5 to 7 nm, and the overall size of the nanoparticles was around 20, 60, and 150 nm in aqueous solution. The size of the nanoparticles was controlled by the amount of C-16. The 3.0-T MRI signal intensity of a rabbit lymph node was effectively reduced after intravenous administration of PHEA-C-16-iron oxide with the size of 20 nm. The in vitro and in vivo toxicity tests revealed the high biocompatibility of PHEA-C-16-iron oxide nanoparticles. Therefore, PHEA-C-16-iron oxide nanoparticles with 20-nm size can be potentially useful as T2-weighted MR imaging contrast agents for the detection of lymph nodes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGEROPEN | - |
dc.subject | SUPERPARAMAGNETIC IRON-OXIDE | - |
dc.subject | CANCER | - |
dc.subject | METASTASES | - |
dc.subject | COPOLYMERS | - |
dc.subject | AGENT | - |
dc.subject | ACID | - |
dc.title | Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yuk, Soon Hong | - |
dc.identifier.doi | 10.1186/1556-276X-9-38 | - |
dc.identifier.scopusid | 2-s2.0-84928409887 | - |
dc.identifier.wosid | 000336027600001 | - |
dc.identifier.bibliographicCitation | NANOSCALE RESEARCH LETTERS, v.9 | - |
dc.relation.isPartOf | NANOSCALE RESEARCH LETTERS | - |
dc.citation.title | NANOSCALE RESEARCH LETTERS | - |
dc.citation.volume | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.subject.keywordPlus | SUPERPARAMAGNETIC IRON-OXIDE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | METASTASES | - |
dc.subject.keywordPlus | COPOLYMERS | - |
dc.subject.keywordPlus | AGENT | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordAuthor | Magnetic resonance imaging | - |
dc.subject.keywordAuthor | Lymph node | - |
dc.subject.keywordAuthor | Ultrasuperparamagnetic iron oxide | - |
dc.subject.keywordAuthor | Nanoparticles | - |
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