Effect of Mesenchymal Stem Cells and Extracts Derived from the Placenta on Trophoblast Invasion and Immune Responses
DC Field | Value | Language |
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dc.contributor.author | Choi, Jong Ho | - |
dc.contributor.author | Jung, Jieun | - |
dc.contributor.author | Na, Kyu-Hwan | - |
dc.contributor.author | Cho, Kyung Jin | - |
dc.contributor.author | Yoon, Tae Ki | - |
dc.contributor.author | Kim, Gi Jin | - |
dc.date.accessioned | 2021-09-05T12:17:45Z | - |
dc.date.available | 2021-09-05T12:17:45Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-01-15 | - |
dc.identifier.issn | 1547-3287 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99535 | - |
dc.description.abstract | Tightly regulated trophoblast invasion and immunomodulation at the feto-maternal interface is important during implantation and fetal development. Although trophoblasts as a pregnancy-specific cell has been reported to be a key factor capable of regulating certain events during implantation, however, its regulatory mechanisms are still unclear. In this study, we analyzed the effects of chorionic plate-derived mesenchymal stem cells (CP-MSCs) and human placenta extract (hPE) isolated from human normal placentas on trophoblasts invasion and immune responses. We investigated the effects of CP-MSCs, hPE treatment, and their combination on trophoblasts invasion and on T-cells suppression through human leukocyte antigen-G (HLA-G) expression. Trophoblasts invasion was significantly increased by co-culture of CP-MSCs or by hPE treatment (P<0.05), and enhanced by the combination of CP-MSCs and hPE treatment (P<0.05). The proliferation of T-cells was decreased by co-culture of CP-MSCs and hPE treatment, whereas the population of regulatory T-cells was increased (P<0.05). Also, the dynamics alterations of multiple cytokines were observed in the culture supernatants of trophoblasts and T-cells depending on CP-MSCs co-culture and hPE treatment. Interestingly, the concentration of soluble HLA-G was increased by CP-MSCs co-culture, by hPE treatment and by combination of them on trophoblasts and activated T-cells (P<0.05). These findings suggested that CP-MSCs and hPE can regulate trophoblasts invasion and T-cell by alteration of HLA-G expression. These results will provide understandings of trophoblasts invasion and the immunological network at the feto-maternal interface during pregnancy and contribute to the foundation of a new treatment strategy for pregnancy disorders. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | REGULATORY T-CELLS | - |
dc.subject | SOLUBLE HLA-G | - |
dc.subject | MOLECULES INDUCE APOPTOSIS | - |
dc.subject | IN-VITRO | - |
dc.subject | STROMAL CELLS | - |
dc.subject | BONE-MARROW | - |
dc.subject | METALLOPROTEINASE ACTIVITY | - |
dc.subject | RAT MODEL | - |
dc.subject | NK CELLS | - |
dc.subject | SUPPRESSION | - |
dc.title | Effect of Mesenchymal Stem Cells and Extracts Derived from the Placenta on Trophoblast Invasion and Immune Responses | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Kyung Jin | - |
dc.identifier.doi | 10.1089/scd.2012.0674 | - |
dc.identifier.scopusid | 2-s2.0-84891842020 | - |
dc.identifier.wosid | 000329356800006 | - |
dc.identifier.bibliographicCitation | STEM CELLS AND DEVELOPMENT, v.23, no.2, pp.132 - 145 | - |
dc.relation.isPartOf | STEM CELLS AND DEVELOPMENT | - |
dc.citation.title | STEM CELLS AND DEVELOPMENT | - |
dc.citation.volume | 23 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 132 | - |
dc.citation.endPage | 145 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | SOLUBLE HLA-G | - |
dc.subject.keywordPlus | MOLECULES INDUCE APOPTOSIS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | METALLOPROTEINASE ACTIVITY | - |
dc.subject.keywordPlus | RAT MODEL | - |
dc.subject.keywordPlus | NK CELLS | - |
dc.subject.keywordPlus | SUPPRESSION | - |
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