Efficacy of Short-Term Growth Hormone Treatment in Prepubertal Children with Idiopathic Short Stature
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ho-Seong | - |
dc.contributor.author | Yang, Sei Won | - |
dc.contributor.author | Yoo, Han-Wook | - |
dc.contributor.author | Suh, Byung Kyu | - |
dc.contributor.author | Ko, Cheol Woo | - |
dc.contributor.author | Chung, Woo Yeong | - |
dc.contributor.author | Lee, Kee Hyoung | - |
dc.contributor.author | Hwang, Jin Soon | - |
dc.contributor.author | Ji, Hyi-Jeong | - |
dc.contributor.author | Ahn, Hyunji | - |
dc.contributor.author | Kim, Duk Hee | - |
dc.date.accessioned | 2021-09-05T12:28:49Z | - |
dc.date.available | 2021-09-05T12:28:49Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-01-01 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99579 | - |
dc.description.abstract | Purpose: It has been reported that daily recombinant human growth hormone (GH) treatment showed beneficial effects on growth in prepubertal children with idiopathic short stature (ISS). The present study aimed to validate the GH (Eutropin (R)) effect on growth promotion and safety after short-term GH treatment. Materials and Methods: This study was an open-label, multicenter, interventional study conducted at nine university hospitals in Korea between 2008 and 2009. Thirty six prepubertal children with ISS were enrolled in this study to receive 6-month GH treatment. Yearly growth rate, height standard deviation score (SDS), and adverse events were investigated during treatment. Results: After 26 weeks of OH treatment, the height velocity significantly increased by 6.36 +/- 3.36 cm/year (p<0.001). The lower end of one-sided 95% confidence interval was 5.22 cm/year, far greater than the predefined effect size. The gain in height SDS at week 26 was 0.57 +/- 0.27 (p<0.0001). Bone age significantly increased after GH treatment, however, bone maturation rate (bone age for chronological age) showed limited advancement. This 26-week GH treatment was effective in increasing serum levels of insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3 from baseline (p<0.0001). Eutropin was well tolerated and there were no withdrawals due to adverse events. No clinically significant changes in laboratory values were observed. Conclusion: This 6-month daily GH treatment in children with ISS demonstrated increased height velocity, improved height SDS, and increased IGF-I and IGFBP-3 levels with a favorable safety profile. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | YONSEI UNIV COLL MEDICINE | - |
dc.subject | CONTROLLED TRIAL | - |
dc.subject | THERAPY | - |
dc.subject | DEFICIENCY | - |
dc.subject | HEIGHT | - |
dc.subject | MATURATION | - |
dc.subject | MANAGEMENT | - |
dc.subject | CHILDHOOD | - |
dc.subject | PUBERTY | - |
dc.subject | AGE | - |
dc.title | Efficacy of Short-Term Growth Hormone Treatment in Prepubertal Children with Idiopathic Short Stature | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kee Hyoung | - |
dc.identifier.doi | 10.3349/ymj.2014.55.1.53 | - |
dc.identifier.scopusid | 2-s2.0-84890775229 | - |
dc.identifier.wosid | 000330142300008 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, v.55, no.1, pp.53 - 60 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.citation.title | YONSEI MEDICAL JOURNAL | - |
dc.citation.volume | 55 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 53 | - |
dc.citation.endPage | 60 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001834767 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | CONTROLLED TRIAL | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | DEFICIENCY | - |
dc.subject.keywordPlus | HEIGHT | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | CHILDHOOD | - |
dc.subject.keywordPlus | PUBERTY | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordAuthor | Treatment outcome | - |
dc.subject.keywordAuthor | safety | - |
dc.subject.keywordAuthor | growth hormone | - |
dc.subject.keywordAuthor | child | - |
dc.subject.keywordAuthor | short stature | - |
dc.subject.keywordAuthor | idiopathic | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.