Exogenous rhTRX reduces lipid accumulation under LPS-induced inflammation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Gi-Yeon | - |
dc.contributor.author | Lee, Eun-Kyung | - |
dc.contributor.author | Park, Hey-won | - |
dc.contributor.author | Kim, Hyun-Jung | - |
dc.contributor.author | Kim, Chan-Wha | - |
dc.date.accessioned | 2021-09-05T12:35:02Z | - |
dc.date.available | 2021-09-05T12:35:02Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99618 | - |
dc.description.abstract | Redox-regulating molecule, recombinant human thioredoxin (rhTRX) which shows anti-inflammatory, and anti-oxidative effects against lipopolysaccharide (LPS)-stimulated inflammation and regulate protein expression levels. LPS-induced reactive oxygen intermediates (ROI) and NO production were inhibited by exogenous rhTRX. We identified up/downregulated intracellular proteins under the LPS-treated condition in exogenous rhTRX-treated A375 cells compared with non-LPS-treated cells via 2-DE proteomic analysis. Also, we quantitatively measured cytokines of in vivo mouse inflammation models using cytometry bead array. Exogenous rhTRX inhibited LPS-stimulated production of ROI and NO levels. TIP47 and ATP synthase may influence the inflammation-related lipid accumulation by affecting lipid metabolism. The modulation of skin redox environments during inflammation is most likely to prevent alterations in lipid metabolism through upregulation of TIP47 and ATP synthase and downregulation of inflammatory cytokines. Our results demonstrate that exogenous rhTRX has anti-inflammatory properties and intracellular regulatory activity in vivo and in vitro. Monitoring of LPS-stimulated pro-inflammatory conditions treated with rhTRX in A375 cells could be useful for diagnosis and follow-up of inflammation reduction related with candidate proteins. These results have a therapeutic role in skin inflammation therapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | LUNG INFLAMMATION | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | THIOREDOXIN | - |
dc.subject | PROTEIN | - |
dc.subject | METABOLISM | - |
dc.subject | DROPLETS | - |
dc.subject | INDUCTION | - |
dc.subject | MEMBRANE | - |
dc.title | Exogenous rhTRX reduces lipid accumulation under LPS-induced inflammation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chan-Wha | - |
dc.identifier.doi | 10.1038/emm.2013.136 | - |
dc.identifier.scopusid | 2-s2.0-84896879407 | - |
dc.identifier.wosid | 000342288100002 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.46 | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 46 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001846543 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | LUNG INFLAMMATION | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | THIOREDOXIN | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | DROPLETS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | lipid accumulation | - |
dc.subject.keywordAuthor | rhTRX | - |
dc.subject.keywordAuthor | skin cell proteomics | - |
dc.subject.keywordAuthor | TIP47 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.