Associations between interleukin 1 polymorphisms and susceptibility to systemic lupus erythematosus: A meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Seo, Young Ho | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-05T12:38:37Z | - |
dc.date.available | 2021-09-05T12:38:37Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 0198-8859 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99641 | - |
dc.description.abstract | Objective: This study determined whether interleukin 1 (IL1) polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE). Methods: A meta-analysis was conducted on the associations between the IL1A, IL1B, and IL1 receptor antagonist (IL1 RN) polymorphisms and SLE. Results: A total of 15 studies involving 1956 SLE cases and 2347 controls were included in the meta-analysis. The meta-analysis showed an association between SLE and the IL1A -889 T allele in the overall population and Europeans (OR = 0.858, 95% CI = 0.737-0.986, p = 0.032; OR = 0.827, 95% CI = 0.687-0.994, p = 0.043). Meta-analysis of the IL1 RN polymorphism revealed an association with SLE in all study subjects (OR for IL1RN*2 = 1.539, 95% CI = 1.266-1.871, p = 1.5 x 10(-2)) and in Europeans and Asians (OR = 1.483, 95% CI = 1.187-1.852, p = 0.001; OR = 1.787, 95% CI = 1.167-2.736, p = 0.008). No associations were found between SLE and the IL1B -511 C/T, 3953 C/T, and IL1A +4845 G/T polymorphisms. Conclusions: This meta-analysis suggests IL1A 889 C/T polymorphism is associated with susceptibility to SLE in Europeans, and that the IL1 RN*2 allele is associated with susceptibility to SLE in Europeans and Asians. (C) 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | ANTAGONIST GENE POLYMORPHISM | - |
dc.subject | IL-1 RECEPTOR ANTAGONIST | - |
dc.subject | GENOME SCAN METAANALYSIS | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | IL-1-BETA GENE | - |
dc.subject | JAPANESE PATIENTS | - |
dc.subject | DISEASE-ACTIVITY | - |
dc.subject | CHINESE PATIENTS | - |
dc.subject | PLASMA-LEVELS | - |
dc.subject | SERUM-LEVELS | - |
dc.title | Associations between interleukin 1 polymorphisms and susceptibility to systemic lupus erythematosus: A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hoon | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Ji, Jong Dae | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1016/j.humimm.2013.09.002 | - |
dc.identifier.scopusid | 2-s2.0-84890211336 | - |
dc.identifier.wosid | 000330155900019 | - |
dc.identifier.bibliographicCitation | HUMAN IMMUNOLOGY, v.75, no.1, pp.105 - 112 | - |
dc.relation.isPartOf | HUMAN IMMUNOLOGY | - |
dc.citation.title | HUMAN IMMUNOLOGY | - |
dc.citation.volume | 75 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 105 | - |
dc.citation.endPage | 112 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | ANTAGONIST GENE POLYMORPHISM | - |
dc.subject.keywordPlus | IL-1 RECEPTOR ANTAGONIST | - |
dc.subject.keywordPlus | GENOME SCAN METAANALYSIS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | IL-1-BETA GENE | - |
dc.subject.keywordPlus | JAPANESE PATIENTS | - |
dc.subject.keywordPlus | DISEASE-ACTIVITY | - |
dc.subject.keywordPlus | CHINESE PATIENTS | - |
dc.subject.keywordPlus | PLASMA-LEVELS | - |
dc.subject.keywordPlus | SERUM-LEVELS | - |
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