Associations between TNF-alpha-308 A/G and lymphotoxin-alpha+252 A/G polymorphisms and susceptibility to sarcoidosis: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-05T12:42:09Z | - |
dc.date.available | 2021-09-05T12:42:09Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99663 | - |
dc.description.abstract | Several studies have examined the effects of the tumor necrosis factor-alpha (TNF-alpha) -308 A/G and lymphotoxin-alpha (LT-alpha) +252 A/G polymorphisms on susceptibility to sarcoidosis, showing mixed results. The purpose of this study was to examine whether the TNF-alpha -308 A/G and LT-alpha +252 A/G polymorphisms confer susceptibility to sarcoidosis. We did a literature search from MEDLINE and EMBASE indices, and conducted a meta-analysis examining the association between TNF-alpha -308 A/G and LT-alpha +252 A/G polymorphisms and sarcoidosis. A total of 13 separate comparisons including 1,396 patients with sarcoidosis and 2,344 controls were considered in our meta-analysis. The meta-analysis revealed a significant association between the TNF-alpha -308 A allele and sarcoidosis (odds ratio [OR] = 1.480, 95 % confidence interval [CI] 1.057-2.073, p = 0.002). Stratification by ethnicity indicated an association between the TNF-alpha -308 A allele polymorphism and sarcoidosis in Europeans (OR = 1.445, 95 % CI = 1.010-2.065, p = 0.044), but not Asians (OR = 4.693, 95 % CI = 0.548-40.29, p = 0.158). The results also showed a significant association between the LT-alpha +252 G allele and sarcoidosis (OR = 1.266, 95 % CI = 1.048-1.528, p = 0.014). Stratification by ethnicity indicated an association between the LT-alpha +252 G allele and sarcoidosis in Europeans (OR = 1.307, 95 % CI = 1.045-1.635, p = 0.019), but not in Asians (OR = 1.169, 95 % CI = 0.824-1.660, p = 0.381). Our meta-analysis demonstrates that the TNF-alpha -308 A/G and LT-alpha +252 A/G polymorphisms are associated with susceptibility to sarcoidosis in an European population. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | TUMOR-NECROSIS-FACTOR | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | TNF-ALPHA | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | PULMONARY SARCOIDOSIS | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | PROMOTER REGION | - |
dc.subject | 1ST INTRON | - |
dc.subject | BETA | - |
dc.subject | PROGNOSIS | - |
dc.title | Associations between TNF-alpha-308 A/G and lymphotoxin-alpha+252 A/G polymorphisms and susceptibility to sarcoidosis: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1007/s11033-013-2859-x | - |
dc.identifier.scopusid | 2-s2.0-84891938930 | - |
dc.identifier.wosid | 000329100500030 | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY REPORTS, v.41, no.1, pp.259 - 267 | - |
dc.relation.isPartOf | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.title | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.volume | 41 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 259 | - |
dc.citation.endPage | 267 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | PULMONARY SARCOIDOSIS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | PROMOTER REGION | - |
dc.subject.keywordPlus | 1ST INTRON | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordAuthor | TNF-alpha | - |
dc.subject.keywordAuthor | LT-alpha | - |
dc.subject.keywordAuthor | Meta-analysis | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Sarcoidosis | - |
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