YKL-40 expression could be a poor prognostic marker in the breast cancer tissue
DC Field | Value | Language |
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dc.contributor.author | Kang, Eun Joo | - |
dc.contributor.author | Jung, Hoiseon | - |
dc.contributor.author | Woo, Ok Hee | - |
dc.contributor.author | Park, Kyong Hwa | - |
dc.contributor.author | Woo, Sang Uk | - |
dc.contributor.author | Yang, Dae Sik | - |
dc.contributor.author | Kim, Ae-Ree | - |
dc.contributor.author | Lee, Jae-Bok | - |
dc.contributor.author | Kim, Yeul Hong | - |
dc.contributor.author | Kim, Jun Suk | - |
dc.contributor.author | Seo, Jae Hong | - |
dc.date.accessioned | 2021-09-05T12:42:43Z | - |
dc.date.available | 2021-09-05T12:42:43Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 1010-4283 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99667 | - |
dc.description.abstract | YKL-40 is a glycoprotein involved in cellular growth, migration, and the inflammatory process. Elevation in serum levels of YKL-40 has been associated with worse prognosis in various cancers, including breast cancer. Given that the clinical significance of YKL-40 expression in breast cancer tissue is unclear, we aimed to determine the prognostic value of YKL-40 expression in breast cancer tissue using immunohistochemistry. We performed tissue microarray (TMA) analysis of 425 breast cancer tissues collected during operation. Immunohistochemical staining was performed to measure expression of YKL-40 and several breast cancer biomarkers, such as aldehyde dehyadrogenase1, TGF-beta, and Gli-1 as well as hormonal receptor and Her-2/neu status. Statistical analysis of the relationship of YKL-40 expression with clinicopathological characteristics was performed for 390 TMA samples. YKL-40 was expressed to varying degrees in 84.9 % of breast cancer tissues. YKL-40 expression was correlated with estrogen receptor and progesterone receptor negativity and was positively correlated with TGF-beta and Gli-1 expression. Strong YKL-40 expression was associated with a larger proportion of Her-2/neu-enriched and basal-like tumors. The results of this study demonstrate that YKL-40 expression in breast cancer tissues is associated with hormone receptor negativity and Her-2/neu-enriched molecular subtypes of breast cancer, and therefore could be considered a poor prognostic predictor. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | HUMAN CARTILAGE GP-39 | - |
dc.subject | SERUM YKL-40 | - |
dc.subject | PROTEIN | - |
dc.subject | CELLS | - |
dc.subject | CHITINASE | - |
dc.subject | LEVEL | - |
dc.subject | BETA | - |
dc.subject | CARCINOMA | - |
dc.subject | CHITOTRIOSIDASE | - |
dc.subject | INFLAMMATION | - |
dc.title | YKL-40 expression could be a poor prognostic marker in the breast cancer tissue | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Eun Joo | - |
dc.contributor.affiliatedAuthor | Woo, Ok Hee | - |
dc.contributor.affiliatedAuthor | Park, Kyong Hwa | - |
dc.contributor.affiliatedAuthor | Woo, Sang Uk | - |
dc.contributor.affiliatedAuthor | Yang, Dae Sik | - |
dc.contributor.affiliatedAuthor | Kim, Ae-Ree | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Bok | - |
dc.contributor.affiliatedAuthor | Kim, Yeul Hong | - |
dc.contributor.affiliatedAuthor | Kim, Jun Suk | - |
dc.contributor.affiliatedAuthor | Seo, Jae Hong | - |
dc.identifier.doi | 10.1007/s13277-013-1036-0 | - |
dc.identifier.scopusid | 2-s2.0-84893721278 | - |
dc.identifier.wosid | 000331091000036 | - |
dc.identifier.bibliographicCitation | TUMOR BIOLOGY, v.35, no.1, pp.277 - 286 | - |
dc.relation.isPartOf | TUMOR BIOLOGY | - |
dc.citation.title | TUMOR BIOLOGY | - |
dc.citation.volume | 35 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 277 | - |
dc.citation.endPage | 286 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | HUMAN CARTILAGE GP-39 | - |
dc.subject.keywordPlus | SERUM YKL-40 | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CHITINASE | - |
dc.subject.keywordPlus | LEVEL | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | CHITOTRIOSIDASE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordAuthor | YKL-40 | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | Prognostic marker | - |
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