The heat-shock protein-70-induced renoprotective effect is partially mediated by CD4(+)CD25(+)Foxp3(+) regulatory T cells in ischemia/reperfusion-induced acute kidney injury
DC Field | Value | Language |
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dc.contributor.author | Kim, Myung-Gyu | - |
dc.contributor.author | Cho, Eun Jung | - |
dc.contributor.author | Lee, Jae Won | - |
dc.contributor.author | Ko, Yoon Sook | - |
dc.contributor.author | Lee, Hee Young | - |
dc.contributor.author | Jo, Sang-Kyung | - |
dc.contributor.author | Cho, Won Yong | - |
dc.contributor.author | Kim, Hyoung Kyu | - |
dc.date.accessioned | 2021-09-05T12:49:10Z | - |
dc.date.available | 2021-09-05T12:49:10Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 0085-2538 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99710 | - |
dc.description.abstract | Recent reports suggest the presence of heat-shock protein (HSP)-reactive T cells with a regulatory phenotype in various inflammatory diseases. To test whether HSP exerts renoprotective effects through regulatory T cells (Tregs), ischemia/reperfusion injury was done with or without heat preconditioning in mice. Splenocytes from heat-preconditioned mice had Treg expansion and a reduced proliferative response upon mitogenic stimulus. T cells from heat-preconditioned mice failed to reconstitute postischemic injury when adoptively transferred to T cell-deficient nu/nu mice in contrast to those from control mice. Tregs were also increased in heat-preconditioned ischemic kidneys. Depleting Tregs before heat preconditioning abolished the renoprotective effect, while adoptive transfer of these cells back into Treg-depleted mice partially restored the beneficial effect of heat preconditioning. Inhibition of HSP70 by quercetin suppressed Treg expansion, as well as renoprotective effects. Transferring Tregs in quercetin-treated heat-preconditioned mice partially restored the beneficial effect of heat preconditioning. The specificity of immune cell HSP70 in renoprotection was confirmed by partial restoration of kidney injury when T cells from HSP70-deficient heat preconditioned mice were adoptively transferred to nu/nu mice. Thus, the renoprotective effect of HSP70 may be partially mediated by a direct immunomodulatory effect through Tregs. Better understanding of immunomodulatory mechanisms of various stress proteins might facilitate discovery of new preventive strategies in acute kidney injury. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | JUVENILE IDIOPATHIC ARTHRITIS | - |
dc.subject | ADJUVANT ARTHRITIS | - |
dc.subject | CHRONIC INFLAMMATION | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | RENAL INJURY | - |
dc.subject | HEAT-SHOCK-PROTEIN-70 | - |
dc.subject | PROTEINS | - |
dc.subject | INDUCTION | - |
dc.subject | IMMUNOMODULATION | - |
dc.subject | HYPERTHERMIA | - |
dc.title | The heat-shock protein-70-induced renoprotective effect is partially mediated by CD4(+)CD25(+)Foxp3(+) regulatory T cells in ischemia/reperfusion-induced acute kidney injury | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Myung-Gyu | - |
dc.contributor.affiliatedAuthor | Jo, Sang-Kyung | - |
dc.contributor.affiliatedAuthor | Cho, Won Yong | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung Kyu | - |
dc.identifier.doi | 10.1038/ki.2013.277 | - |
dc.identifier.scopusid | 2-s2.0-84891561636 | - |
dc.identifier.wosid | 000329214500012 | - |
dc.identifier.bibliographicCitation | KIDNEY INTERNATIONAL, v.85, no.1, pp.62 - 71 | - |
dc.relation.isPartOf | KIDNEY INTERNATIONAL | - |
dc.citation.title | KIDNEY INTERNATIONAL | - |
dc.citation.volume | 85 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 62 | - |
dc.citation.endPage | 71 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | JUVENILE IDIOPATHIC ARTHRITIS | - |
dc.subject.keywordPlus | ADJUVANT ARTHRITIS | - |
dc.subject.keywordPlus | CHRONIC INFLAMMATION | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | RENAL INJURY | - |
dc.subject.keywordPlus | HEAT-SHOCK-PROTEIN-70 | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | IMMUNOMODULATION | - |
dc.subject.keywordPlus | HYPERTHERMIA | - |
dc.subject.keywordAuthor | acute kidney injury | - |
dc.subject.keywordAuthor | heat-shock protein-70 | - |
dc.subject.keywordAuthor | immunomodulation | - |
dc.subject.keywordAuthor | regulatory T cells | - |
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