Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction
DC Field | Value | Language |
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dc.contributor.author | Kim, Dae Gyu | - |
dc.contributor.author | Lee, Jin Young | - |
dc.contributor.author | Kwon, Nam Hoon | - |
dc.contributor.author | Fang, Pengfei | - |
dc.contributor.author | Zhang, Qian | - |
dc.contributor.author | Wang, Jing | - |
dc.contributor.author | Young, Nicolas L. | - |
dc.contributor.author | Guo, Min | - |
dc.contributor.author | Cho, Hye Young | - |
dc.contributor.author | Mushtaq, Ameeq Ul | - |
dc.contributor.author | Jeon, Young Ho | - |
dc.contributor.author | Choi, Jin Woo | - |
dc.contributor.author | Han, Jung Min | - |
dc.contributor.author | Kang, Ho Woong | - |
dc.contributor.author | Joo, Jae Eun | - |
dc.contributor.author | Hur, Youn | - |
dc.contributor.author | Kang, Wonyoung | - |
dc.contributor.author | Yang, Heekyoung | - |
dc.contributor.author | Nam, Do-Hyun | - |
dc.contributor.author | Lee, Mi-Sook | - |
dc.contributor.author | Lee, Jung Weon | - |
dc.contributor.author | Kim, Eun-Sook | - |
dc.contributor.author | Moon, Aree | - |
dc.contributor.author | Kim, Kibom | - |
dc.contributor.author | Kim, Doyeun | - |
dc.contributor.author | Kang, Eun Joo | - |
dc.contributor.author | Moon, Youngji | - |
dc.contributor.author | Rhee, Kyung Hee | - |
dc.contributor.author | Han, Byung Woo | - |
dc.contributor.author | Yang, Jee Sun | - |
dc.contributor.author | Han, Gyoonhee | - |
dc.contributor.author | Yang, Won Suk | - |
dc.contributor.author | Lee, Cheolju | - |
dc.contributor.author | Wang, Ming-Wei | - |
dc.contributor.author | Kim, Sunghoon | - |
dc.date.accessioned | 2021-09-05T13:00:37Z | - |
dc.date.available | 2021-09-05T13:00:37Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 1552-4450 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99766 | - |
dc.description.abstract | Lysyl-tRNA synthetase (KRS), a protein synthesis enzyme in the cytosol, relocates to the plasma membrane after a laminin signal and stabilizes a 67-kDa laminin receptor (67LR) that is implicated in cancer metastasis; however, its potential as an antimetastatic therapeutic target has not been explored. We found that the small compound BC-K-YH16899, which binds KRS, impinged on the interaction of KRS with 67LR and suppressed metastasis in three different mouse models. The compound inhibited the KRS-67LR interaction in two ways. First, it directly blocked the association between KRS and 67LR. Second, it suppressed the dynamic movement of the N-terminal extension of KRS and reduced membrane localization of KRS. However, it did not affect the catalytic activity of KRS. Our results suggest that specific modulation of a cancer-related KRS-67LR interaction may offer a way to control metastasis while avoiding the toxicities associated with inhibition of the normal functions of KRS. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | ION-CYCLOTRON RESONANCE | - |
dc.subject | MASS-SPECTROMETRY | - |
dc.subject | SCATTERING SAXS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | CELL INVASION | - |
dc.subject | SYSTEM | - |
dc.subject | CANCER | - |
dc.subject | METASTASIS | - |
dc.subject | CARCINOMA | - |
dc.subject | PROTEINS | - |
dc.title | Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeon, Young Ho | - |
dc.identifier.doi | 10.1038/NCHEMBIO.1381 | - |
dc.identifier.scopusid | 2-s2.0-84891006164 | - |
dc.identifier.wosid | 000328854900007 | - |
dc.identifier.bibliographicCitation | NATURE CHEMICAL BIOLOGY, v.10, no.1, pp.29 - U57 | - |
dc.relation.isPartOf | NATURE CHEMICAL BIOLOGY | - |
dc.citation.title | NATURE CHEMICAL BIOLOGY | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 29 | - |
dc.citation.endPage | U57 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | ION-CYCLOTRON RESONANCE | - |
dc.subject.keywordPlus | MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | SCATTERING SAXS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CELL INVASION | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | PROTEINS | - |
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