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Targeting cancer’s sweet spot: UGP2 as a therapeutic vulnerability
- Kim, S.;
- Wolfe, A.;
- Kim, S.E.
Citations
SCOPUS
11초록
Understanding the mechanisms governing metabolic reprogramming that underlie potential vulnerabilities in cancer cells is key to developing novel therapeutic strategies. The catalytic enzyme UDP-glucose pyrophosphorylase 2 (UGP2) drives the production of UDP-glucose. Our recent work demonstrated the crucial role of UGP2 in cancer growth and its regulation of cellular metabolic processes. © 2021 Taylor & Francis Group, LLC.
키워드
cancer metabolism; glycosylation; UDP-glucose; UGP2; YAP
- 제목
- Targeting cancer’s sweet spot: UGP2 as a therapeutic vulnerability
- 저자
- Kim, S.; Wolfe, A.; Kim, S.E.
- 발행일
- 2021
- 유형
- Article
- 권
- 8
- 호
- 6