Thickness-radius relationship and spring constants of cholesterol helical ribbons

  • Khaykovich, Boris
  • Kozlova, Natalia
  • Choi, Wonshik
  • Lomakin, Aleksey
  • Hossain, Chintan
  • 외 4명
Citations

WEB OF SCIENCE

10
Citations

SCOPUS

11

초록

Using quantitative phase microscopy, we have discovered a quadratic relationship between the radius R and the thickness t of helical ribbons that form spontaneously in multicomponent cholesterol-surfactant mixtures. These helical ribbons may serve as mesoscopic springs to measure or to exert forces on nanoscale biological objects. The spring constants of these helices depend on their submicroscopic thickness. The quadratic relationship (R proportional to t(2)) between radius and thickness is a consequence of the crystal structure of the ribbons and enables a determination of the spring constant of any of our helices solely in terms of its observable geometrical dimensions.

키워드

biological force spectroscopyelasticity of thin filmsphase-contrast microscopy in biophysicsCRYSTALLIZATIONTUBULESFILMS
제목
Thickness-radius relationship and spring constants of cholesterol helical ribbons
저자
Khaykovich, BorisKozlova, NataliaChoi, WonshikLomakin, AlekseyHossain, ChintanSung, YongjinDasari, Ramachandra R.Feld, Michael S.Benedek, George B.
DOI
10.1073/pnas.0907795106
발행일
2009-09-15
유형
Article
저널명
Proceedings of the National Academy of Sciences of the United States of America
106
37
페이지
15663 ~ 15666