Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo

Wu, Peng; Song, Ziteng; Wang, Xuelian; Li, Ying; Li, Yuhao; Cui, Jianlin; Tuerhong, Muhetaer; Jin, Da-Qing; Abudukeremu, Munira; Lee, Dongho; Xu, Jing; Guo, Yuanqiang

doi:10.1016/j.bioorg.2020.104004

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Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo

Wu, Peng;
Song, Ziteng;
Wang, Xuelian;
Li, Ying;
Li, Yuhao;
... Lee, Dongho;
외 6명

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31

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38

초록

Bioactive natural products play an important role in the research and development of new drugs. In our search for bioactive natural substances as potential lead compounds for inflammation, four new (1-4) and six known (6-10) triterpenoids were acquired from Lantana camara. Using NMR and MS techniques and electronic circular dichroism (ECD) calculations, these isolates were characterized and the new compounds (1-4) were found to be euphane-type triterpenoids. The in vitro anti-inflammatory effects of all the isolates were evaluated and the more bioactive compounds were selected for the investigation of preliminary mechanism using molecular docking and Western blotting experiments, as well as the in vivo anti-inflammatory evaluation using a zebrafish model.

키워드

Euphane triterpenoids; Anti-inflammatory properties; Molecular docking; Zebrafish model; Lantana camara; ANTI-NEUROINFLAMMATORY AGENTS; PENTACYCLIC TRITERPENOIDS; AERIAL PARTS; INHIBITORY-ACTIVITIES; NATURAL-PRODUCTS; ACID; CONSTITUENTS; INFLAMMATION; LIMONOIDS; LEAVES

제목: Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo

저자: Wu, Peng; Song, Ziteng; Wang, Xuelian; Li, Ying; Li, Yuhao; Cui, Jianlin; Tuerhong, Muhetaer; Jin, Da-Qing; Abudukeremu, Munira; Lee, Dongho; Xu, Jing; Guo, Yuanqiang

DOI: 10.1016/j.bioorg.2020.104004

발행일: 2020-08

유형: Article

저널명: Bioorganic Chemistry

권: 101