C-C Bond Cleavage-Induced C- to N-Acyl Transfer for Synthesis of Amides

초록

"A new approach for the preparation of amides was developed using C-C bond cleavage that initiates C- to N-acyl transfer, employing activated ketones as acylation reagents and amine nucleophiles. The reaction was operational under the coupling reagent system that is commonly utilized for peptide bond formations. The method enables practical preparation of amides using linear and cyclic ketone substrates under mild conditions. (Figure Presented). © 2024 American Chemical Society.

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