Multi-core vesicle nanoparticles for controlled delivery of protein drug

Yuk, Soon Hong; Oh, Keun Sang; Kim, Seung Ki; Lee, Jin Ho; Cho, Sun Hang; Kim, Kwangmeyung; Jeon, Hyesung; Kwon, Ick Chan

doi:10.1007/s13233-012-0053-y

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Multi-core vesicle nanoparticles for controlled delivery of protein drug

Yuk, Soon Hong;
Oh, Keun Sang;
Kim, Seung Ki;
Lee, Jin Ho;
Cho, Sun Hang;
외 3명

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초록

The Pluronic/poly(ethylene glycol) composite nanoparticles (NPs) composed of Pluronic F-68, liquid poly(ethylene glycol) (PEG; molecular weight, 400) and human growth hormone (hGH) were stabilized with the vesicle fusion. When hGH-loaded Pluronic/PEG composite NPs were mixed with vesicles in the aqueous medium, hGH-loaded Pluronic/PEG composite NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using field emission scanning electron microscopy, cryo-transmission electron microscopy, and a particle size analyzer. When multi-core vesicle NPs were applied as a delivery system for the protein drug, a sustained release pattern of hGH was observed.

키워드

human growth hormone; Pluronic/PEG composite NPs; multi-core vesicle NPs; peptide drug; sustained release; GH-DEFICIENT PATIENTS; GROWTH-HORMONE GH; COPOLYMER; FUSION; ENCAPSULATION; MICROSPHERES; SPECTROSCOPY; STABILITY; BILAYER; SYSTEMS

제목: Multi-core vesicle nanoparticles for controlled delivery of protein drug

저자: Yuk, Soon Hong; Oh, Keun Sang; Kim, Seung Ki; Lee, Jin Ho; Cho, Sun Hang; Kim, Kwangmeyung; Jeon, Hyesung; Kwon, Ick Chan

DOI: 10.1007/s13233-012-0053-y

발행일: 2012-03

유형: Article

저널명: Macromolecular Research

권: 20

호: 3

페이지: 309 ~ 312