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17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception
- Bang, S.;
- Yoo, S.;
- Yang, T. J.;
- Cho, H.;
- Hwang, S. W.
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WEB OF SCIENCE
119Citations
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133초록
BACKGROUND AND PURPOSE Transient receptor potential ion channel vanilloid 3 (TRPV3) is expressed in skin keratinocytes and plays an important role in thermal and chemical nociceptions in the periphery. The presence of TRPV3 inhibitors would improve our understanding of TRPV3 function and help to develop receptor-specific analgesics. However, little is known about physiological substances that specifically inhibit TRPV3 activity. Here, we investigated whether 17(R)-resolvin D1 (17R-RvD1), a naturally occurring pro-resolving lipid specifically affects TRPV3 activity.
키워드
17(R)-resolvin D1; TRPV3; specific inhibitor; pain; keratinocytes; nociceptive behaviours; inflammation; RESOLVIN D1; CAPSAICIN RECEPTOR; INFLAMMATORY HYPERALGESIA; MECHANICAL HYPERALGESIA; NOCICEPTIVE NEURONS; SENSORY NEURONS; PAIN; ACTIVATION; TRPV3; BRADYKININ
- 제목
- 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception
- 저자
- Bang, S.; Yoo, S.; Yang, T. J.; Cho, H.; Hwang, S. W.
- 발행일
- 2012-02
- 유형
- Article
- 권
- 165
- 호
- 3
- 페이지
- 683 ~ 692