Metal-free approach for the L-proline mediated synthesis of nitrones from nitrosobenzene

초록

An efficient, and metal-free approach for the L-proline mediated synthesis of nitrones from nitro-sobenzene and benzaldehydes has been established. The reaction undergoes very efficiently at room temperature in methanol as a solvent. The reaction is assumed to involve that the initial formation of azomethine ylide and [2 + 3] cycloaddition of nitrosobenzene, followed by the subsequent retro [2 + 3] cycloaddition could offer the desired nitrone. (c) 2018 Elsevier Ltd. All rights reserved.

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