An iminocoumarin-Cu(II) ensemble-based chemodosimeter toward thiols

  • Jung, Hyo Sung
  • Han, Ji Hye
  • Habata, Yoichi
  • Kang, Chulhun
  • Kim, Jong Seung
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초록

An 'ensemble'-based fluoregenic chemodosimeter 1-Cu(II) for detection of thiols is reported. Complex 1-Cu(II) sensitively senses thiols followed by hydrolysis to give a marked fluorescence enhancement over other amino acids at pH 7.4 under aqueous media. Confocal microscopic imaging of complex 1-Cu(II) is also herewith demonstrated for cellular thiol detection in HepG2 cells.

키워드

GLUTATHIONE-REDUCTASEFLUORESCENT-PROBEAQUEOUS-SOLUTIONCYSTEINEHOMOCYSTEINERHODAMINEWATERSPIROLACTAMDISEASESENSOR
제목
An iminocoumarin-Cu(II) ensemble-based chemodosimeter toward thiols
저자
Jung, Hyo SungHan, Ji HyeHabata, YoichiKang, ChulhunKim, Jong Seung
DOI
10.1039/c1cc10672d
발행일
2011
유형
Article
저널명
Chemical Communications
47
18
페이지
5142 ~ 5144