Enhanced delivery of the phototherapeutic nanoparticles via hepatocyte overload

Kim, Jae Yeon; Kil, Ye Chan; Yang, Da Hye; Park, Dal Yong; Jang, Hee Jun; Park, Song-Kyu; Jung, Yong Woo; Yoon, Hong Yeol; Kim, Kwangmeyung; Song, Daesub; Yuk, Soon Hong

doi:10.1016/j.colsurfb.2022.112959

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Enhanced delivery of the phototherapeutic nanoparticles via hepatocyte overload

Kim, Jae Yeon;
Kil, Ye Chan;
Yang, Da Hye;
Park, Dal Yong;
Jang, Hee Jun;
... Jung, Yong Woo;
외 5명

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초록

Phototherapeutic nanoparticles (NPs) were prepared with methylene blue (MB), indocyanine green (ICG), and Solutol through self-assembly. Generation of reactive oxygen species and elevation of temperature were observed that verify the photodynamic/photothermal effects of the NPs. Morphology and size distribution of the NPs were examined by transmittance electron microscopy and dynamic light scattering. The biodistribution of the NPs and their antitumor efficacy were examined using tumor-bearing mice to understand the phototherapeutic effect of the NPs on tumors. To enhance targetability with enhanced therapeutic efficacy, empty NPs (Solutol nano -particles without MB and ICG) at different concentrations were injected along with the phototherapeutic NPs. Enhanced delivery of the phototherapeutic NPs at the tumor site was examined based on hepatocyte overload.

키워드

Phototheraputic nanoparticles; Methylene blue; Indocyanine green; Solutol; Hepatocyte overload; NIR PHOTOTHERMAL THERAPY; GOLD NANOPARTICLES; MIXED MICELLES; COMBINATION; METASTASIS

제목: Enhanced delivery of the phototherapeutic nanoparticles via hepatocyte overload

저자: Kim, Jae Yeon; Kil, Ye Chan; Yang, Da Hye; Park, Dal Yong; Jang, Hee Jun; Park, Song-Kyu; Jung, Yong Woo; Yoon, Hong Yeol; Kim, Kwangmeyung; Song, Daesub; Yuk, Soon Hong

DOI: 10.1016/j.colsurfb.2022.112959

발행일: 2023-01-01

유형: Article

저널명: Colloids and Surfaces B: Biointerfaces

권: 221