Modulation of ethanol-induced P450 enzyme activities and antioxidants in mice by Hordeum vulgare extract

Lee, Y.-H.; Lee, J.; Im, E.-J.; Jun, W.; Cho, H.Y.

doi:10.3746/jkfn.2009.38.10.1347

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Modulation of ethanol-induced P450 enzyme activities and antioxidants in mice by Hordeum vulgare extract

Lee, Y.-H.;
Lee, J.;
Im, E.-J.;
Jun, W.;
Cho, H.Y.

Citations

SCOPUS

7

초록

The effects of methanol extract of barely (Hordeum vulgare) on alcohol-induced damages of liver were investigated in male ICR mice. Mice were divided into three groups, control, ethanol, and ethanol plus 0.15% of barley extract. After four weeks of ethanol feeding, ethanol group significantly increased the P450 content, CYP2E1 and CYP1A2 enzyme activities, whereas ethanol plus barely group markedly decreased to levels similar to control group. Catalase activity in ethanol group was significantly lower than that in control group; however, ethanol plus barely group stimulated catalase activity as well as SOD activity significantly. These results indicated that barely extract modulated P450 enzymes for ethanol-induced liver damage and might be useful in developing functional food for alcoholic liver damage.

키워드

Alcohol; Cytochrome P450; Hepatoprotective effect; Hordeum vulgare; Oxidative damage; Hordeum; Hordeum vulgare; Mus

제목: Modulation of ethanol-induced P450 enzyme activities and antioxidants in mice by Hordeum vulgare extract

저자: Lee, Y.-H.; Lee, J.; Im, E.-J.; Jun, W.; Cho, H.Y.

DOI: 10.3746/jkfn.2009.38.10.1347

발행일: 2009

유형: Article

저널명: 한국식품영양과학회지

권: 38

호: 10

페이지: 1347 ~ 1352