A coumarin-naphthalimide hybrid as a dual emissive fluorescent probe for hNQO1

Park, Sun Young; Won, Miae; Kang, Chulhun; Kim, Jong Seung; Lee, Min Hee

doi:10.1016/j.dyepig.2019.01.050

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A coumarin-naphthalimide hybrid as a dual emissive fluorescent probe for hNQO1

Park, Sun Young;
Won, Miae;
Kang, Chulhun;
Kim, Jong Seung;
Lee, Min Hee

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WEB OF SCIENCE

33

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34

초록

hNQO1 is a promising target for cancer diagnosis and treatment. Here, we developed a coumarin-naphthalimide hybrid (1) as a dual emissive fluorescent probe that enhances the emission through hNQO1-mediated cleavage of its trimethyl lockquinone moiety. Probe 1 can be used for a real-time monitoring of hNQO1 activity in living cells.

키워드

hNQO1 detection; Dual emission imaging; Naphthalimide; Coumarin; DT-DIAPHORASE; TURN-ON; 1 NQO1; CANCER

제목: A coumarin-naphthalimide hybrid as a dual emissive fluorescent probe for hNQO1

저자: Park, Sun Young; Won, Miae; Kang, Chulhun; Kim, Jong Seung; Lee, Min Hee

DOI: 10.1016/j.dyepig.2019.01.050

발행일: 2019-05

유형: Article

저널명: Dyes and Pigments

권: 164

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