Toward practical machine-learning-based diagnosis for drug-naive women with major depressive disorder using EEG channel reduction approach

초록

Background: A machine-learning-based computer-aided diagnosis (CAD) system can complement the traditional diagnostic error for major depressive disorder (MDD) using trait-like neurophysiological biomarkers. Previous studies have shown that the CAD system has the potential to differentiate between female MDD patients and healthy controls. The aim of this study was to develop a practically useful resting-state electroencephalography (EEG)-based CAD system to assist in the diagnosis of drug-naive female MDD patients by considering both the drug and gender effects. In addition, the feasibility of the practical use of the resting-state EEG-based CAD system was evaluated using a channel reduction approach. Methods: Eyes-closed, resting-state EEG data were recorded from 49 drug-naive female MDD patients and 49 sex -matched healthy controls. Six different EEG feature sets were extracted: power spectrum densities (PSDs), phase -locking values (PLVs), and network indices for both sensor-and source-level, and four different EEG channel montages (62, 30, 19, and 10-channels) were designed to investigate the channel reduction effects in terms of classification performance. Results: The classification performances for each feature set were evaluated using a support vector machine with leave-one-out cross-validation. The optimum classification performance was achieved when using sensor-level PLVs (accuracy: 83.67 % and area under curve: 0.92). Moreover, the classification performance was main-tained until the number of EEG channels was reduced to 19 (over 80 % accuracy). Conclusion: We demonstrated the promising potential of sensor-level PLVs as diagnostic features when devel-oping a resting-state EEG-based CAD system for the diagnosis of drug-naive female MDD patients and verified the feasibility of the practical use of the developed resting-state EEG-based CAD system using the channel reduction approach.

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