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A novel t(8;13)(q21;q22) translocation in a pediatric lipoma
- Jin, Jinglan;
- Niu, Junqi;
- Kim, Young-Mi;
- Wang, Xianfu;
- Parham, David;
- ... Lee, Ji-Yun;
- 외 2명
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4초록
Pediatric lipomas are rare and their etiology is unknown. As in adult lipomas, a segment of 12q13-q15 has been documented as a common chromosomal rearrangement region. Here, we report a pediatric lipoma case without rearrangement of 12q13-q15 but with an apparently balanced translocation involving chromosomes 8 and 13 [t(8;13)(q21;q22)] detected by routine cytogenetic analysis, and small deletions on 5q21.1 and 8q21.11 detected by array comparative genetic hybridization. The small deletion on 8q21.11 is possibly due to chromosomal instability at the breakpoint of the translocation.
키워드
Lipoma; chromosomal translocation; array CGH; FISH; DERIVATIVE CHROMOSOME-9; CYTOGENETIC ANALYSIS; MYXOID LIPOSARCOMA; HIGH-RESOLUTION; DELETIONS; TUMORS; FUSION; REARRANGEMENT; BENIGN
- 제목
- A novel t(8;13)(q21;q22) translocation in a pediatric lipoma
- 저자
- Jin, Jinglan; Niu, Junqi; Kim, Young-Mi; Wang, Xianfu; Parham, David; Letton, Robert; Li, Shibo; Lee, Ji-Yun
- 발행일
- 2011-11
- 유형
- Editorial Material
- 저널명
- Cancer Genetics
- 권
- 204
- 호
- 11
- 페이지
- 629 ~ 633