Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS

Dong, Bangjian; An, Lijun; Yang, Xueyuan; Zhang, Xuke; Zhang, Jie; Tuerhong, Muhetaer; Jin, Da-Qing; Ohizumi, Yasushi; Lee, Dongho; Xu, Jing; Guo, Yuanqiang

doi:10.1016/j.bioorg.2019.03.051

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Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS

Dong, Bangjian;
An, Lijun;
Yang, Xueyuan;
Zhang, Xuke;
Zhang, Jie;
... Lee, Dongho;
외 5명

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37

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42

초록

A phytochemical study to obtain new nitric oxide (NO) inhibitors resulted in the isolation of five new with-anolides from the whole plants of Physalis peruviana. The structures were determined on the basis of extensive NMR spectroscopic data analysis as well as the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The NO inhibitory effects were examined by inhibiting NO release in lipopolysaccharide-stimulated murine microglial BV-2 cells. Molecular docking studies showed the strong interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein, revealing the potential mechanism of NO inhibition of bioactive compounds.

키워드

Physalis peruviana; Withanolides; NO inhibitors; Molecular docking; iNOS; INFLAMMATION; TRITERPENOIDS; PUBESCENS; TOXICITY

제목: Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS

저자: Dong, Bangjian; An, Lijun; Yang, Xueyuan; Zhang, Xuke; Zhang, Jie; Tuerhong, Muhetaer; Jin, Da-Qing; Ohizumi, Yasushi; Lee, Dongho; Xu, Jing; Guo, Yuanqiang

DOI: 10.1016/j.bioorg.2019.03.051

발행일: 2019-06

유형: Article

저널명: Bioorganic Chemistry

권: 87

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