Ursolic acid is a PPAR-alpha agonist that regulates hepatic lipid metabolism

Jia, Yaoyao; Bhuiyan, Muhammad Javidul Haque; Jun, Hee-jin; Lee, Ji Hae; Hoang, Minh Hien; Lee, Hak-Ju; Kim, Nahyun; Lee, Dongho; Hwang, Kwang Yeon; Hwang, Bang Yeon; Choi, Dal-Woong; Lee, Sung-Joon

doi:10.1016/j.bmcl.2011.07.095

상세 보기

Ursolic acid is a PPAR-alpha agonist that regulates hepatic lipid metabolism

Jia, Yaoyao;
Bhuiyan, Muhammad Javidul Haque;
Jun, Hee-jin;
Lee, Ji Hae;
Hoang, Minh Hien;
... Lee, Dongho;
... Choi, Dal-Woong;
... Lee, Sung-Joon;
외 4명

Citations

WEB OF SCIENCE

88

Citations

SCOPUS

94

초록

In this study, we confirmed that ursolic acid, a plant triterpenoid, activates peroxisome proliferator-activated receptor (PPAR)-alpha in vitro. Surface plasmon resonance and time-resolved fluorescence resonance energy transfer analyses do not show direct binding of ursolic acid to the ligand-binding domain of PPAR-alpha; however, ursolic acid enhances the binding of PPAR-alpha to the peroxisome proliferator response element in PPAR-alpha-responsive genes, alters the expression of key genes in lipid metabolism, significantly reducing intracellular triglyceride and cholesterol concentrations in hepatocytes. Thus, ursolic acid is a PPAR-alpha agonist that regulates the expression of lipid metabolism genes, but it is not a direct ligand of PPAR-alpha. (C) 2011 Elsevier Ltd. All rights reserved.

키워드

Ursolic acid; PPAR-alpha; Agonist; Lipid metabolism; Hepatocyte; PROLIFERATOR-ACTIVATED-RECEPTOR; OLEANOLIC ACID; GENE; TRANSCRIPTION; CHOLESTEROL; PATHWAYS; GAMMA

제목: Ursolic acid is a PPAR-alpha agonist that regulates hepatic lipid metabolism

저자: Jia, Yaoyao; Bhuiyan, Muhammad Javidul Haque; Jun, Hee-jin; Lee, Ji Hae; Hoang, Minh Hien; Lee, Hak-Ju; Kim, Nahyun; Lee, Dongho; Hwang, Kwang Yeon; Hwang, Bang Yeon; Choi, Dal-Woong; Lee, Sung-Joon

DOI: 10.1016/j.bmcl.2011.07.095

발행일: 2011-10-01

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 21

호: 19

페이지: 5876 ~ 5880