상세 보기
Coumarin-Based Thiol Chemosensor: Synthesis, Turn-On Mechanism, and Its Biological Application
- Jung, Hyo Sung;
- Ko, Kyoung Chul;
- Kim, Gun-Hee;
- Lee, Ah-Rah;
- Na, Yun-Cheol;
- ... Kim, Jong Seung;
- 외 2명
Citations
WEB OF SCIENCE
196Citations
SCOPUS
203초록
A new chemodosimetric probe (1) is reported that selectively detects thiols over other relevant biological species by the turning on of its fluorescence through a Michael type reaction. The fluorogenic process upon its reaction was revealed to be mediated by intramolecular charge transfer, as confirmed by time-dependent density functional theory calculations. The application of probe 1 to cells is also examined by confocal microscopy, and its cysteine preference was observed by an ex vivo LC-MS analysis of the cellular metabolite.
키워드
FLUORESCENT; CYSTEINE; GLUTATHIONE; PROBE; HOMOCYSTEINE; RHODAMINE; PLASMA; WATER; IONS
- 제목
- Coumarin-Based Thiol Chemosensor: Synthesis, Turn-On Mechanism, and Its Biological Application
- 저자
- Jung, Hyo Sung; Ko, Kyoung Chul; Kim, Gun-Hee; Lee, Ah-Rah; Na, Yun-Cheol; Kang, Chulhun; Lee, Jin Yong; Kim, Jong Seung
- 발행일
- 2011-03-18
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 13
- 호
- 6
- 페이지
- 1498 ~ 1501