Susceptibility of human H3N2 influenza virus to oseltamivir in South Korea, 2009-2011

Park, Sehee; Kim, Jin Il; Lee, Ilseob; Lee, Sangmoo; Hwang, Min-Woong; Bae, Joon-Yong; Heo, Jun; Lim, Eun-Joo; Seok, Won-Seok; Cheong, Hee Jin; Song, Joon Young; Kim, Woo Joo; Park, Man-Seong

doi:10.1007/s12275-012-2541-3

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Susceptibility of human H3N2 influenza virus to oseltamivir in South Korea, 2009-2011

Park, Sehee;
Kim, Jin Il;
Lee, Ilseob;
Lee, Sangmoo;
Hwang, Min-Woong;
... Cheong, Hee Jin;
... Song, Joon Young;
외 6명

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5

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SCOPUS

6

초록

During the 2009-2011 influenza seasons, 10.26% of the specimens isolated from patients in South Korea were subtyped as H3N2 viruses. Some oseltamivir-sensitive H3N2 samples exhibited different plaque morphologies, and were found to have novel mutations in the neuraminidase gene. In a subsequent analysis using NA mutant viruses, viral compensation against oseltamivir treatment was observed only in the N2 mutant virus. All things considered, these novel mutations may account for the exclusive characteristics of selected H3N2 viruses observed in plaque reduction assays.

키워드

influenza; neuraminidase; oseltamivir; UNITED-STATES; NEURAMINIDASE INHIBITORS; A VIRUSES; RESISTANCE; SEASON; H1N1; SURVEILLANCE; WORLDWIDE

제목: Susceptibility of human H3N2 influenza virus to oseltamivir in South Korea, 2009-2011

저자: Park, Sehee; Kim, Jin Il; Lee, Ilseob; Lee, Sangmoo; Hwang, Min-Woong; Bae, Joon-Yong; Heo, Jun; Lim, Eun-Joo; Seok, Won-Seok; Cheong, Hee Jin; Song, Joon Young; Kim, Woo Joo; Park, Man-Seong

DOI: 10.1007/s12275-012-2541-3

발행일: 2012-12

유형: Article

저널명: Journal of Microbiology

권: 50

호: 6

페이지: 1067 ~ 1070