Bioactive diterpenoids from Trigonostemon chinensis: Structures, NO inhibitory activities, and interactions with iNOS

Xu, Jing; Peng, Maoqin; Sun, Xiaocong; Liu, Xingyu; Tong, Ling; Su, Guochen; Ohizumi, Yasushi; Lee, Dongho; Guo, Yuanqiang

doi:10.1016/j.bmcl.2016.08.026

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Bioactive diterpenoids from Trigonostemon chinensis: Structures, NO inhibitory activities, and interactions with iNOS

Xu, Jing;
Peng, Maoqin;
Sun, Xiaocong;
Liu, Xingyu;
Tong, Ling;
... Lee, Dongho;
외 3명

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22

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SCOPUS

25

초록

A phytochemical investigation to obtain new NO inhibitors led to the isolation of two new (1 and 2) and four known (3-6) diterpenoids from Trigonostemon chinensis. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analyses, and the absolute configurations of new compounds were established by experimental and calculated ECD spectra. The inhibitory activities on lipopolysaccharide-induced NO production in murine microglial BV-2 cells of these diterpenoids were evaluated, and all of the compounds showed inhibitory effects. The interactions of bioactive compounds with iNOS protein were also studied by molecular docking. (C) 2016 Elsevier Ltd. All rights reserved.

키워드

Trigonostemon chinensis; Diterpenoids; NO inhibitory activities; iNOS; Molecular docking; DAPHNANE-TYPE DITERPENOIDS; NITRIC-OXIDE SYNTHASE; CHEMICAL-CONSTITUENTS; NEURITE OUTGROWTH; PC12 CELLS; LII; XYPHOPHYLLOIDES; HETEROPHYLLUS; STEMS; LEAVES

제목: Bioactive diterpenoids from Trigonostemon chinensis: Structures, NO inhibitory activities, and interactions with iNOS

저자: Xu, Jing; Peng, Maoqin; Sun, Xiaocong; Liu, Xingyu; Tong, Ling; Su, Guochen; Ohizumi, Yasushi; Lee, Dongho; Guo, Yuanqiang

DOI: 10.1016/j.bmcl.2016.08.026

발행일: 2016-10-01

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 26

호: 19

페이지: 4785 ~ 4789

언어: ENG

출판사: PERGAMON-ELSEVIER SCIENCE LTD

발행국가: 영국

분량: 5 페이지

ISSN: E 1464-3405
P 0960-894X